Evaluating Antiinflammatory and Antiandrogenic Effects of Garden Cress (Lepidium Sativum L.) in HaCaT Cells

    June 2018 in “ Records of Natural Products ”
    Murat Türkoğlu, Songül Kılıç, Erkin Pekmezci, Murat Kartal
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    TLDR Garden cress extract may help treat skin inflammation and androgen-related disorders.
    The study from 2018 evaluated the effects of garden cress (Lepidium sativum L.) leaf extract on human keratinocyte cells (HaCaT) and found that the extract significantly reduced the gene expression of vascular endothelial growth factor (VEGF), tumor necrosis factor-alpha (TNF-α), and 5 alpha-reductase type II (SRD5A2), which are associated with inflammation and androgenic effects. However, interleukin 1-alpha (IL-1α) was not significantly affected. The presence of phenolic compounds like ferulic acid in the extract may contribute to its therapeutic effects. The findings suggest potential benefits for treating inflammatory and androgen-dependent skin disorders, but the document lacks specific data on clinical studies and the number of participants involved.
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