Effect of Ficus Carica Leaf Extract on the Gene Expression of Selected Factors in HaCaT Cells
April 2017
in “
Journal of Cosmetic Dermatology
”
Ficus carica VEGF TNF-α IL-1α SRD5A2 human keratinocyte HaCaT cells anti-inflammatory anti-androgenic androgenetic alopecia fig leaf extract vascular endothelial growth factor tumor necrosis factor alpha interleukin-1 alpha steroid 5 alpha-reductase type 2 keratinocyte hair loss inflammation androgenic hair loss
TLDR Ficus carica leaf extract may help treat skin disorders by reducing inflammation and androgen effects in skin cells.
The study from April 22, 2017, found that Ficus carica (Fc) leaf extract significantly downregulated the gene expression of VEGF, TNF-α, IL-1α, and SRD5A2 in human keratinocyte (HaCaT) cells. These results suggest that Fc leaf extract has anti-inflammatory and anti-androgenic properties, potentially making it useful for treating skin disorders, including androgen-dependent conditions like androgenetic alopecia. The findings provide a molecular explanation for the traditional use of Fc in treating various skin diseases and indicate its potential for developing new treatments for inflammatory and androgen-dependent skin disorders. Further clinical studies are needed to confirm these effects.
