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GlossaryInterleukin-1 alpha

promotes inflammation and influences hair follicle biology

Interleukin-1 alpha (IL-1α) is a type of protein known as a cytokine, which plays a crucial role in the body's immune response by promoting inflammation. It is involved in various cellular activities, including cell proliferation, differentiation, and apoptosis. In the context of hair and alopecia, IL-1α can influence hair follicle biology and has been implicated in inflammatory conditions that may lead to hair loss.

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research Minoxidil downregulates Interleukin-1 alpha gene expression in HaCaT cells

16 citations , January 2018 in “International Journal of Trichology”

Minoxidil may help treat hair loss by reducing inflammation-related gene activity in skin cells.

Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice

research Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice

7 citations , February 2023 in “Inflammation and Regeneration”

The protein interleukin-1 alpha helps regenerate hair follicles and increase stem cell growth in mice.

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community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 448 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.