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Glossary Pro-inflammatory cytokines

signaling molecules that trigger inflammation in the body

Pro-inflammatory cytokines are signaling molecules released by immune cells that promote inflammation in the body. They play a crucial role in the immune response by helping to fight off infections and heal injuries, but excessive or chronic production can lead to inflammatory diseases such as rheumatoid arthritis, psoriasis, and alopecia areata. Examples include tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1), and interleukin-6 (IL-6).

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Research

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research Advanced glycation end-products inhibit mesenchymal-epidermal interaction by up-regulating proinflammatory cytokines in hair follicles

3 citations , July 2015 in “European Journal of Dermatology”

This abstract discusses the role of advanced glycation end-products in aging-related skin damage, but does not provide new findings on their impact on alopecia.

research The effects of methylated flavonoids on depression-like activity and pro-inflammatory cytokine thresholds in mice induced by repeated finasteride administration

1 citations , January 2021 in “European Journal of Inflammation”

In this study, naringenin and its methylated derivatives reduced depression-like behaviors and inflammation markers in mice exposed to finasteride, suggesting their potential as effective and safe anti-depressive agents.

research FC053 Pro-inflammatory cytokine cascade in human plucked hair

September 1997 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Anti-IL-1 treatments might help with certain types of hair loss in people with high inflammation.

research Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization

65 citations , June 2020 in “Stem Cell Research & Therapy”

This review discusses recent advances in how proinflammatory cytokines affect epidermal stem cell function during skin wound healing and introduces potential therapies targeting these cells and cytokines.

research A new TH17 cytokine in hidradenitis suppurativa: antimicrobial and pro-inflammatory role of IL-26

March 2020

This study evaluated interleukin-26's antimicrobial activity in Hidradenitis Suppurativa and explored its potential role in chronic skin inflammation.

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community Short Peptides for Hair Loss: anyone tried any of these?

14 upvotes 5 months ago

Various peptides are discussed for treating male pattern baldness, with some available for topical use like GHK-Cu and Ac-KGHK, while others remain in research stages. Users are interested in experiences and sourcing these treatments.

community Reversed my hairloss without fin/min. 2023 December to 2025 April. IDK what happened.

565 upvotes 1 year ago

A user reversed hair loss using 10% sulfur soap, which reduced scalp inflammation and possibly demodex mites. The user did not use finasteride or minoxidil, suggesting inflammation may contribute to hair loss.

community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

121 upvotes 2 years ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Subcutaneous Scalp fat and Hair loss? Interested in others annecdotal experience or knowledge.

6 upvotes 3 years ago

Subcutaneous scalp fat may be linked to hair loss, with theories suggesting that fat loss can lead to reduced blood flow and increased DHT activity, contributing to hair loss. Treatments discussed include PRP/PRF injections and fat transfer to improve scalp thickness and blood flow.

community Someone please offer reassurance

in Minoxidil 3 upvotes 1 month ago

A 19-year-old male is experiencing hair shedding while using oral minoxidil, ketoconazole, dermastamping, and saw palmetto, and is considering switching to finasteride for better results. Users suggest that saw palmetto may not be effective and recommend finasteride instead, while also discussing other treatments like rosemary oil, peppermint oil, and pumpkin seed oil.

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learn Stem Cell Factor

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Omega 3

Is the omega-3 to omega-6 ratio in your diet feeding your hair problem without you knowing? Nutrition sources describe a lopsided omega-6 to omega-3 intake as pro-inflammatory, but no published human study shows that the dietary ratio changes 5-alpha reductase, scalp DHT or hair loss; the one relevant trial tested a commercial omega-3/6 plus antioxidant supplement in 120 women, not a change in dietary fat ratio.

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