The Effects of Methylated Flavonoids on Depression-Like Activity and Pro-Inflammatory Cytokine Thresholds in Mice Induced by Repeated Finasteride Administration

    January 2021 in “ European Journal of Inflammation ”
    Bin She, Huajin Wu, Qin Xie, Mingjuan Zhang, Nan Zhou, Deyu Pei, Zheming Tu
    TLDR Methylated flavonoids may effectively reduce depression and inflammation caused by finasteride.
    The study investigated the effects of naringenin (NGN) and its methylated derivatives on depression-like behavior and inflammation in 168 male mice induced by finasteride. Finasteride increased immobility in behavioral tests and elevated brain levels of pro-inflammatory cytokines IL-1β and TNF-α. Treatment with NGN or its derivatives (50 or 100 mg/kg) reduced immobility, restored sucrose preference, and normalized cytokine levels, similar to duloxetine (10 mg/kg). Additionally, NGN and its derivatives improved antioxidant levels, indicating their potential as safe and effective anti-depressive agents. The findings suggested that methylated flavonoids could enhance therapeutic effects by improving metabolic stability and bioavailability.
    Discuss this study in the Community →

    Research cited in this study

    5 / 5 results

    Related Community Posts Join

    6 / 1000+ results

      community Oral Minoxidil and Grapefruit Juice

      in Research/Science  96 upvotes 1 year ago
      The conversation is about the potential dangers of taking oral minoxidil and grapefruit juice together. Some users express concern about dangerous drug interactions, while others argue that grapefruit juice may inhibit the metabolism of finasteride. The conclusion is that grapefruit juice may make finasteride less effective, but it won't affect minoxidil.

      community Getting Ed from 1mg of fin not sure what to do

      in Finasteride  190 upvotes 3 months ago
      The user experienced erectile dysfunction from 1mg finasteride and sought advice on whether to continue, reduce dosage, or switch treatments. Suggestions included switching to topical finasteride, adding minoxidil, or trying dutasteride.

      community Topical finasteride in liposomal formulation

      in Finasteride  5 upvotes 4 years ago
      Topical finasteride in a liposomal formulation reduces systemic absorption compared to ethanol solutions. The user is seeking sources for such products, noting that popular options like morr-f are not liposomal.

      community 10 Years on Fin + Min: My story & insight on sides.

      in Finasteride  130 upvotes 4 years ago
      User shares 10-year experience using Finasteride and Minoxidil for hair loss with positive results and no significant side effects. Others suggest consistency, microneedling, and considering hair transplants.

      community Dutasteride Mega Guide – Better Than Finasteride?

      in Finasteride  88 upvotes 4 years ago
      The potential risks and benefits of using Dutasteride as a hair loss treatment, compared to using Finasteride or other treatments like RU58841 or Accutane. People discussed their personal experiences with these treatments and shared advice on how to proceed.

    Related Research

    2 / 2 results