The Effects of Methylated Flavonoids on Depression-Like Activity and Pro-Inflammatory Cytokine Thresholds in Mice Induced by Repeated Finasteride Administration

    January 2021 in “ European Journal of Inflammation
    Bin She, Huajin Wu, Qin Xie, Mingjuan Zhang, Nan Zhou, Deyu Pei, Zheming Tu
    TLDR Methylated flavonoids may effectively reduce depression and inflammation caused by finasteride.
    The study investigated the effects of naringenin (NGN) and its methylated derivatives on depression-like behavior and inflammation in 168 male mice induced by finasteride. Finasteride increased immobility in behavioral tests and elevated brain levels of pro-inflammatory cytokines IL-1β and TNF-α. Treatment with NGN or its derivatives (50 or 100 mg/kg) reduced immobility, restored sucrose preference, and normalized cytokine levels, similar to duloxetine (10 mg/kg). Additionally, NGN and its derivatives improved antioxidant levels, indicating their potential as safe and effective anti-depressive agents. The findings suggested that methylated flavonoids could enhance therapeutic effects by improving metabolic stability and bioavailability.
    Discuss this study in the Community →

    Research cited in this study

    5 / 5 results

    Related Community Posts Join

    6 / 1000+ results

      community Oral Minoxidil and Grapefruit Juice

      in Research/Science  96 upvotes 2 years ago
      The conversation is about the potential dangers of taking oral minoxidil and grapefruit juice together. Some users express concern about dangerous drug interactions, while others argue that grapefruit juice may inhibit the metabolism of finasteride. The conclusion is that grapefruit juice may make finasteride less effective, but it won't affect minoxidil.
      27M on Finasteride/Minoxidil 8-9 Months, Considering Dutasteride for Hair Loss

      community 27M on Finasteride/Minoxidil 8-9 Months, Considering Dutasteride for Hair Loss

      in Finasteride  71 upvotes 6 days ago
      The user has been using finasteride and minoxidil for 8-9 months without significant improvement in hair loss and is considering switching to dutasteride and topical minoxidil. Another user suggests that dutasteride might be more effective due to its potency and advises patience as hair regrowth can take up to a year.

      community 18M: Side Effects After 3 Months on Topical Finasteride

      in Finasteride  102 upvotes 1 week ago
      An 18-year-old using topical finasteride for hair loss is experiencing side effects like delayed ejaculation and lower sex drive after three months. They are considering whether to continue with the treatment or adjust it, possibly switching back to minoxidil.

      community When should I start using Finasteride (21M)

      in Finasteride  68 upvotes 2 weeks ago
      A 21-year-old male recently had a hair transplant and is considering starting finasteride to prevent further hair loss. Finasteride can be started immediately to maintain existing hair, with potential side effects like decreased libido, and results may take several months.

    Related Research

    2 / 2 results