The Effects of Methylated Flavonoids on Depression-Like Activity and Pro-Inflammatory Cytokine Thresholds in Mice Induced by Repeated Finasteride Administration

January 2021 in “ European Journal of Inflammation ”

Bin She, Huajin Wu, Qin Xie, Mingjuan Zhang, Nan Zhou, Deyu Pei, Zheming Tu

finasteride naringenin methylated flavonoids pro-inflammatory cytokines IL-1β TNF-α duloxetine antioxidant levels Propecia NGN Cymbalta

Studysummary In this study, naringenin and its methylated derivatives reduced depression-like behaviors and inflammation markers in mice exposed to finasteride, suggesting their potential as effective and safe anti-depressive agents.

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research Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date

32 citations , March 2020 in “Drug Design Development and Therapy”

This review examines the pharmacology, clinical efficacy, and adverse effects of oral finasteride for female pattern hair loss, and discusses potential new treatments like topical finasteride and dutasteride, but reports no new clinical results.

research Repeated Finasteride Administration Induces Depression-Like Behavior in Adult Male Rats

19 citations , March 2019 in “Behavioural Brain Research”

This study found that repeated finasteride administration in male Wistar rats led to increased depression-like behavior, suggesting an animal model for investigating finasteride's neuropsychiatric effects is viable.

research Effects of Subchronic Finasteride Treatment and Withdrawal on Neuroactive Steroid Levels and Their Receptors in the Male Rat Brain

33 citations , December 2015 in “Neuroendocrinology”

This study found that subchronic finasteride treatment in male rats altered neuroactive steroid levels and steroid receptor expression in the brain, with some changes persisting after drug withdrawal.

research Finasteride Treatment Inhibits Adult Hippocampal Neurogenesis in Male Mice

32 citations , May 2010 in “Pharmacopsychiatry”

This article investigates whether finasteride influences adult hippocampal neurogenesis related to depression and reports no new clinical findings; the authors suggest further research on its neurosteroid inhibition.

research Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism

61 citations , January 2008 in “Biological & Pharmaceutical Bulletin”

In this study, finasteride dose-dependently inhibited stress-induced increases in allopregnanolone in rats, while enhancing 20alpha-reduction of progesterone without affecting 3alpha-dihydroprogesterone or 11-deoxycorticosterone levels.

research Changes in Progesterone Metabolites in the Hippocampus Can Modulate Open Field and Forced Swim Test Behavior of Proestrous Rats

269 citations , May 2002 in “Hormones and Behavior”

Lowering 3α,5α-THP in the hippocampus increases anxiety and depression in proestrous rats.