The Effects of Methylated Flavonoids on Depression-Like Activity and Pro-Inflammatory Cytokine Thresholds in Mice Induced by Repeated Finasteride Administration

    January 2021 in “ European Journal of Inflammation ”
    Bin She, Huajin Wu, Qin Xie, Mingjuan Zhang, Nan Zhou, Deyu Pei, Zheming Tu
    TLDR Methylated flavonoids may effectively reduce depression and inflammation caused by finasteride.
    The study investigated the effects of naringenin (NGN) and its methylated derivatives on depression-like behavior and inflammation in 168 male mice induced by finasteride. Finasteride increased immobility in behavioral tests and elevated brain levels of pro-inflammatory cytokines IL-1β and TNF-α. Treatment with NGN or its derivatives (50 or 100 mg/kg) reduced immobility, restored sucrose preference, and normalized cytokine levels, similar to duloxetine (10 mg/kg). Additionally, NGN and its derivatives improved antioxidant levels, indicating their potential as safe and effective anti-depressive agents. The findings suggested that methylated flavonoids could enhance therapeutic effects by improving metabolic stability and bioavailability.
    Discuss this study in the Community →

    Research cited in this study

    5 / 5 results

    Related Community Posts Join

    6 / 1000+ results

      community Oral Minoxidil and Grapefruit Juice

      in Research/Science  96 upvotes 1 year ago
      The conversation is about the potential dangers of taking oral minoxidil and grapefruit juice together. Some users express concern about dangerous drug interactions, while others argue that grapefruit juice may inhibit the metabolism of finasteride. The conclusion is that grapefruit juice may make finasteride less effective, but it won't affect minoxidil.

      community Post FUE finasteride - moved from oral to topical

      in Finasteride  90 upvotes 6 days ago
      The user switched from oral to topical finasteride with minoxidil after a hair transplant and is experiencing increased hair growth in unexpected areas like eyebrows and sideburns. They are seeking feedback from others with similar experiences.

    Related Research

    2 / 2 results