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    Effects of Subchronic Finasteride Treatment and Withdrawal on Neuroactive Steroid Levels and Their Receptors in the Male Rat Brain

    December 2015 in “ Neuroendocrinology ”
    Silvia Giatti, Benedetta Foglio, Simone Romano … Roberto Cosimo Melcangi
    Studysummary This study found that subchronic finasteride treatment in male rats altered neuroactive steroid levels and steroid receptor expression in the brain, with some changes persisting after drug withdrawal.
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    Research cited in this study 31

    1. Adverse Effects of 5α-Reductase Inhibitors: What Do We Know, Don't Know, and Need to Know? Reviews in Endocrine and Metabolic Disorders · 2015
    2. Safety Concerns Regarding 5α Reductase Inhibitors for the Treatment of Androgenetic Alopecia Current Opinion in Endocrinology, Diabetes and Obesity · 2015
    3. New Steps Forward in the Neuroactive Steroid Field The Journal of Steroid Biochemistry and Molecular Biology · 2015
    4. Immunohistochemical Evaluation of Androgen Receptor and Nerve Structure Density in Human Prepuce from Patients with Persistent Sexual Side Effects after Finasteride Use for Androgenetic Alopecia PLOS ONE · 2014
    5. Patients Treated for Male Pattern Hair Loss with Finasteride Show Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma After Discontinuation The Journal of Steroid Biochemistry and Molecular Biology · 2014
    6. Novel Anticonvulsive Effects of Progesterone in a Mouse Model of Hippocampal Electrical Kindling Neuroscience · 2013
    7. Neuroactive Steroid Levels Are Modified in Cerebrospinal Fluid and Plasma of Post-Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology The Journal of Sexual Medicine · 2013
    8. Central 5-Alpha Reduction of Testosterone Is Required for Testosterone's Inhibition of the Hypothalamo-Pituitary-Adrenal Axis Response to Restraint Stress in Adult Male Rats Brain Research · 2013
    9. Neonatal Neurosteroid Levels Are Determinant in Shaping Adult Prepulse Inhibition Response to Hippocampal Allopregnanolone in Rats Psychoneuroendocrinology · 2013
    10. Alteration of Neonatal Allopregnanolone Levels Affects Exploration, Anxiety, Aversive Learning, and Adult Behavioral Response to Intrahippocampal Neurosteroids Behavioural Brain Research · 2012
    11. Depressive Symptoms and Suicidal Thoughts Among Former Users of Finasteride With Persistent Sexual Side Effects The Journal of Clinical Psychiatry · 2012
    12. Persistent Sexual Side Effects of Finasteride: Could They Be Permanent? The Journal of Sexual Medicine · 2012
    13. 5α-Reductases in Human Physiology: An Unfolding Story Endocrine Practice · 2012
    14. Effects of Oral Finasteride on Erectile Function in a Rat Model The Journal of Sexual Medicine · 2012
    15. Inhibition of 5α-Reductase Activity in Late Pregnancy Decreases Gestational Length and Fecundity and Impairs Object Memory and Central Progestogen Milieu of Juvenile Rat Offspring Journal of Neuroendocrinology · 2011
    16. Progesterone Inhibits the Growth of Human Neuroblastoma: In Vitro and In Vivo Evidence Molecular Medicine · 2011
    17. Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011
    18. Isolation Rearing-Induced Reduction of Brain 5α-Reductase Expression: Relevance to Dopaminergic Impairments Neuropharmacology · 2011
    19. Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010
    20. SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder Cell · 2010
    21. Fadrozole And Finasteride Exposures Modulate Sex Steroid- And Thyroid Hormone-Related Gene Expression In Silurana (Xenopus) Tropicalis Early Larval Development General and Comparative Endocrinology · 2009
    22. Neurosteroids And Epileptogenesis In The Pilocarpine Model: Evidence For A Relationship Between P450scc Induction And Length Of The Latent Period Epilepsia · 2009
    23. Inhibition of 5α-Reduced Steroid Biosynthesis Impedes Acquisition of Ethanol Drinking in Male C57BL/6J Mice Alcoholism Clinical and Experimental Research · 2008
    24. Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism Biological & Pharmaceutical Bulletin · 2008
    25. The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride Journal of The American Academy of Dermatology · 2006
    26. Finasteride Induced Depression: A Prospective Study BMC clinical pharmacology · 2006
    27. Reduced Metabolites Mediate Neuroprotective Effects of Progesterone in the Adult Rat Hippocampus. The Synthetic Progestin Medroxyprogesterone Acetate (Provera) Is Not Neuroprotective Journal of Neurobiology · 2006
    28. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006
    29. Depression Related to Finasteride Administration for Androgenetic Alopecia Journal of Dermatology · 2002
    30. Finasteride Drugs · 1999
    31. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998

    Related research 3

    1. Effects of Subchronic Finasteride Treatment and Withdrawal on Neuroactive Steroid Levels and Their Receptors in the Male Rat Brain Neuroendocrinology · 2015
    2. Testosterone Modulation of Seizure Susceptibility Is Mediated by Neurosteroids 3α-Androstanediol and 17β-Estradiol Neuroscience · 2004
    3. Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men The Journal of Clinical Endocrinology and Metabolism · 1992