Inhibition of 5α-Reductase Activity in Late Pregnancy Decreases Gestational Length and Fecundity and Impairs Object Memory and Central Progestogen Milieu of Juvenile Rat Offspring

    September 2011 in “ Journal of Neuroendocrinology ”
    J. J. Paris, Paula J. Brunton, John A. Russell … Cheryl A. Frye
    Studysummary In this study, inhibiting the formation of 5α-reduced steroids in pregnant rats shortened gestation time, reduced litter size, and impaired cognitive and neuroendocrine function in their juvenile offspring.
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    Research cited in this study 7

    1. Finasteride Treatment of Hair Loss in Women Annals of Pharmacotherapy · 2010
    2. Central Opioid Inhibition of Neuroendocrine Stress Responses in Pregnancy in the Rat Is Induced by the Neurosteroid Allopregnanolone Journal of Neuroscience · 2009
    3. Finasteride Delays the Onset of Maternal Behavior in Primigravid Rats Physiology & Behavior · 2006
    4. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006
    5. A New Look at the 5α-Reductase Inhibitor Finasteride 2006
    6. Hippocampal 3α,5α-THP May Alter Depressive Behavior of Pregnant and Lactating Rats Pharmacology Biochemistry and Behavior · 2004
    7. Effects of In Utero Exposure to Finasteride on Androgen-Dependent Reproductive Development in Male Rats Toxicological Sciences · 2003

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