Finasteride Inhibits the Progesterone-Induced Spike-Wave Discharges in a Genetic Model of Absence Epilepsy

    July 2003 in “ Pharmacology, Biochemistry and Behavior ”
    Gilles van Luijtelaar, Bogusława Budziszewska, Magdalena Tetich, Władysław Lasoń
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    Studysummary Finasteride blocks progesterone's effect on absence seizures in rats. Our plain-language summary of this paper — not a Tressless recommendation.
    The study found that finasteride, an inhibitor of 5a-reductase, blocked the effect of progesterone on absence seizures in male WAG/Rij rats. The results suggest that it is not progesterone itself, but its metabolite produced by 5a-reductase that is involved in the modulation of absence epilepsy. Finasteride alone had no significant effect on spontaneous SWD in WAG/Rij rats.
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