TLDR Finasteride blocks progesterone's effect on absence seizures in rats.
The study found that finasteride, an inhibitor of 5a-reductase, blocked the effect of progesterone on absence seizures in male WAG/Rij rats. The results suggest that it is not progesterone itself, but its metabolite produced by 5a-reductase that is involved in the modulation of absence epilepsy. Finasteride alone had no significant effect on spontaneous SWD in WAG/Rij rats.
65 citations
,
October 2008 in “Journal of Neuroendocrinology” 269 citations
,
May 2002 in “Hormones and Behavior” Lowering 3α,5α-THP in the hippocampus increases anxiety and depression in proestrous rats.
269 citations
,
May 2002 in “Journal of Neuroscience” Stress increases neurosteroids that help prevent seizures.
17 citations
,
September 2013 in “The International Journal of Neuropsychopharmacology” 
34 citations
,
June 2011 in “Alcoholism: Clinical and Experimental Research” Three drugs change mice's alcohol drinking patterns by affecting GABAA receptors.
61 citations
,
January 2008 in “Biological & Pharmaceutical Bulletin” Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.
34 citations
,
April 2007 in “Neuroscience” Finasteride reduces alcohol withdrawal severity in male mice but increases it in female mice.
26 citations
,
November 2006 in “Pharmacology, Biochemistry and Behavior” Pregnancy reduces anxiety in rats, but finasteride reverses this effect.
