Finasteride Inhibits the Progesterone-Induced Spike-Wave Discharges in a Genetic Model of Absence Epilepsy

July 2003 in “ Pharmacology, Biochemistry and Behavior ”

Gilles van Luijtelaar, Bogusława Budziszewska, Magdalena Tetich, Władysław Lasoń

finasteride 5a-reductase progesterone Propecia

TLDR Finasteride blocks progesterone's effect on absence seizures in rats.

The study found that finasteride, an inhibitor of 5a-reductase, blocked the effect of progesterone on absence seizures in male WAG/Rij rats. The results suggest that it is not progesterone itself, but its metabolite produced by 5a-reductase that is involved in the modulation of absence epilepsy. Finasteride alone had no significant effect on spontaneous SWD in WAG/Rij rats.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

research Finasteride Blocks the Reduction in Ictal Activity Produced by Exogenous Estrous Cyclicity

65 citations, October 2008 in “Journal of Neuroendocrinology”

Related Community Posts Join

6 / 1000+ results

community Trying to understand finasteride side effects and post finasteride syndrome

in Finasteride/Dutasteride 73 upvotes 4 years ago

The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

community Proof that finasteride messes with neurosteroids

in Research/Science 230 upvotes 5 months ago

Finasteride can impact neurosteroids, potentially causing depression and other side effects in some users. Despite these concerns, many continue using it for hair loss, with some switching to topical applications to mitigate side effects.

community What Works to Restore Hairloss for Cis-Males? Not Much

in Treatment 18 upvotes 4 years ago

Hair regrowth treatments for cis-males include Minoxidil, Finasteride, and RU58841. Estrogen and testosterone blockers can help restore hair loss but may not suit everyone.

community Spironolactone for 11 years, finasteride for almost 5 years, started oral minoxidil in November 😢 ended oral contraceptive in Dec.

in Progress Pictures 224 upvotes 8 months ago

A user shared their 11-year experience with spironolactone and nearly 5 years with finasteride for hair loss, recently adding oral minoxidil and stopping birth control. Various treatments were discussed, including organic options, checking for underlying health issues, considering dutasteride, and the potential role of progesterone in hair loss.

community Progressive insomnia (treatment-resistant) due to Finasteride

in Finasteride/Dutasteride 7 upvotes 2 years ago

A medical student experienced hair loss slowing with Finasteride but developed severe, treatment-resistant insomnia. They tried various medications with little effect, suspecting Post-Finasteride Syndrome, and others suggested the insomnia might be linked to Finasteride's impact on neurosteroids.

community My muscles & butt are disappearing on finas, and I’m only taking it because my hair was vanishing too. Help! Details below.

in Finasteride/Dutasteride 7 upvotes 3 years ago

A 39 year old female who has been taking finasteride for 1.5 months and is experiencing side effects such as muscle and butt shrinkage, and weight loss despite still having tight clothing. The user is seeking advice from those with knowledge of bodybuilding and hormones to help figure out the issue.

Related Research

5 / 5 results

Neonatal Finasteride Administration Alters Hippocampal α4 and δ GABAAR Subunits Expression and Behavioral Responses to Progesterone in Adult Rats

research Neonatal Finasteride Administration Alters Hippocampal α4 and δ GABAAR Subunits Expression and Behavioral Responses to Progesterone in Adult Rats

17 citations, February 2014 in “The International Journal of Neuropsychopharmacology”

research Alteration of Ethanol Drinking in Mice via Modulation of the GABAA Receptor with Ganaxolone, Finasteride, and Gaboxadol

34 citations, November 2011 in “Alcoholism: Clinical and Experimental Research”

Three drugs change mice's alcohol drinking patterns by affecting GABAA receptors.

research Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism

61 citations, September 2008 in “Biological & Pharmaceutical Bulletin”

Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.

research Sex Differences in the Effect of Finasteride on Acute Ethanol Withdrawal Severity in C57BL/6J and DBA/2J Mice

34 citations, May 2007 in “Neuroscience”

Finasteride reduces alcohol withdrawal severity in male mice but increases it in female mice.

research The Anxiolytic Effect of Pregnancy in Rats Is Reversed by Finasteride

26 citations, November 2006 in “Pharmacology, Biochemistry and Behavior”

Pregnancy reduces anxiety in rats, but finasteride reverses this effect.