Sex Differences in the Effect of Finasteride on Acute Ethanol Withdrawal Severity in C57BL/6J and DBA/2J Mice

    April 2007 in “ Neuroscience ”
    Rebecca E. Gorin-Meyer, Kristine M. Wiren, Michelle A. Tanchuck … Deborah A. Finn
    Studysummary In this study, finasteride altered acute ethanol withdrawal severity differently in male and female mice, highlighting sex differences in sensitivity to changes in neurosteroid levels.
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    Research cited in this study 10

    1. Lack of Evidence of a Role for the Neurosteroid Allopregnanolone in Ethanol-Induced Reward and c-Fos Expression in DBA/2 Mice Brain Research · 2006
    2. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006
    3. Treatment With and Withdrawal From Finasteride Alter Ethanol Intake Patterns in Male C57BL/6J Mice: Potential Role of Endogenous Neurosteroids Alcohol · 2005
    4. GABRA2 Alleles Moderate the Subjective Effects of Alcohol, Which Are Attenuated by Finasteride Neuropsychopharmacology · 2005
    5. Ethanol-Induced Elevation of 3α-Hydroxy-5α-Pregnan-20-One Does Not Modulate Motor Incoordination in Rats Alcoholism Clinical and Experimental Research · 2004
    6. Interaction of Chronic Ethanol Exposure and Finasteride: Sex and Strain Differences Pharmacology, Biochemistry and Behavior · 2004
    7. The Role of Pregnane Neurosteroids in Ethanol Withdrawal: Behavioral Genetic Approaches Pharmacology & Therapeutics · 2004
    8. Testosterone Modulation of Seizure Susceptibility Is Mediated by Neurosteroids 3α-Androstanediol and 17β-Estradiol Neuroscience · 2004
    9. Progesterone Enhances Ethanol-Induced Modulation of Mesocortical Dopamine Neurons: Antagonism by Finasteride Journal of Neurochemistry · 2002
    10. Pharmacokinetic Parameters and Mechanisms of Inhibition of Rat Type 1 and 2 Steroid 5α-Reductases: Determinants for Different In Vivo Activities of GI198745 and Finasteride in the Rat Biochemical Pharmacology · 2001

    Related research 5

    1. Respiratory Regulation by Steroids in Newborn Rats: A Sex-Specific Balance Between Allopregnanolone and Progesterone Receptors Experimental physiology · 2017
    2. Neonatal Finasteride Administration Alters Hippocampal α4 and δ GABAAR Subunits Expression and Behavioral Responses to Progesterone in Adult Rats The International Journal of Neuropsychopharmacology · 2013
    3. Alteration of Ethanol Drinking in Mice via Modulation of the GABAA Receptor with Ganaxolone, Finasteride, and Gaboxadol Alcoholism: Clinical and Experimental Research · 2011
    4. The Anxiolytic Effect of Pregnancy in Rats Is Reversed by Finasteride Pharmacology, Biochemistry and Behavior · 2006
    5. Anxiolytic Activity of Progesterone in Progesterone Receptor Knockout Mice Neuropharmacology · 2004