GABRA2 Alleles Moderate the Subjective Effects of Alcohol, Which Are Attenuated by Finasteride

    June 2005 in “ Neuropsychopharmacology
    Amira Pierucci-Lagha, Jonathan Covault, Richard Feinn, Maggie Nellissery, Carlos A. Hernandez-Avila, Cheryl Oncken, A. Leslie Morrow, Henry R. Kranzler
    Image of study
    TLDR GABRA2 gene variations impact alcohol response, and hair loss medication finasteride reduces some effects.
    This study found that genetic variation in the GABRA2 gene affects the subjective response to alcohol, with individuals homozygous for the A-allele reporting greater effects than those with one or more G-alleles. Finasteride, a medication used to treat hair loss, was found to attenuate some alcohol effects, particularly among A-allele homozygotes. The study suggests that neuroactive steroids mediate a number of the effects of alcohol. The study had limitations, including a small sample size and the lack of a placebo alcohol condition.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 1000+ results

      community Proof that finasteride messes with neurosteroids

      in Research/Science  230 upvotes 1 year ago
      Finasteride can impact neurosteroids, potentially causing depression and other side effects in some users. Despite these concerns, many continue using it for hair loss, with some switching to topical applications to mitigate side effects.

      community Why is Kevin Mann (Haircafe) Hated?

      in Chat  62 upvotes 2 years ago
      Hair loss treatments, including microneedling, minoxidil, finasteride and RU58841; the efficacy of these treatments; criticisms of Kevin Mann's content related to his selective data presentation and biases towards certain treatments; and other topics such as DHT being labeled a "trash hormone" and critiques of other hairloss YouTubers.

      community risks with finasteride and dutasteride

      in Research/Science  138 upvotes 2 weeks ago
      Finasteride and dutasteride have potential risks, including post-finasteride syndrome, but are commonly used for hair loss. RU58841, minoxidil, and needling are suggested as alternatives, though all treatments carry risks.

    Related Research

    2 / 2 results