Lack of Evidence of a Role for the Neurosteroid Allopregnanolone in Ethanol-Induced Reward and c-Fos Expression in DBA/2 Mice

    June 2006 in “ Brain Research ”
    Niall Murphy, Kazuto Sakoori, Chinami Okabe
    TLDR Allopregnanolone likely doesn't influence ethanol's rewarding effects in these mice.
    The study examined whether the neurosteroid allopregnanolone influenced ethanol-induced reward and neural activity in DBA/2 mice, using finasteride to reduce allopregnanolone levels. Despite significantly lowering allopregnanolone, finasteride did not affect ethanol-induced conditioned place preference or alter c-fos expression, indicating that allopregnanolone might not mediate ethanol's rewarding effects. The study involved 6 to 7 mice per group and found that ethanol increased c-fos expression in several brain regions, but finasteride did not significantly change this pattern. These findings suggested that other mechanisms might be responsible for ethanol's effects in this mouse model.
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