Treatment With and Withdrawal From Finasteride Alter Ethanol Intake Patterns in Male C57BL/6J Mice: Potential Role of Endogenous Neurosteroids

    August 2005 in “ Alcohol ”
    Matthew M. Ford, Jeffrey C. Nickel, Deborah A. Finn
    Studysummary This study found that acute finasteride treatment decreased ethanol intake in male C57BL/6J mice, whereas chronic treatment showed diminished effects, implying compensatory changes in neurosteroid modulation.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on sciencedirect.com →
    Discuss this study in the Community →

    Research cited in this study 6

    1. Effects of Finasteride on Chronic and Acute Ethanol Withdrawal Severity in the WSP and WSR Selected Lines Alcoholism: Clinical and Experimental Research · 2005
    2. GABRA2 Alleles Moderate the Subjective Effects of Alcohol, Which Are Attenuated by Finasteride Neuropsychopharmacology · 2005
    3. Ethanol-Induced Elevation of 3α-Hydroxy-5α-Pregnan-20-One Does Not Modulate Motor Incoordination in Rats Alcoholism Clinical and Experimental Research · 2004
    4. Interaction of Chronic Ethanol Exposure and Finasteride: Sex and Strain Differences Pharmacology, Biochemistry and Behavior · 2004
    5. The Role of Pregnane Neurosteroids in Ethanol Withdrawal: Behavioral Genetic Approaches Pharmacology & Therapeutics · 2004
    6. Changes in Progesterone Metabolites in the Hippocampus Can Modulate Open Field and Forced Swim Test Behavior of Proestrous Rats Hormones and Behavior · 2002

    Related research 6

    1. Respiratory Regulation by Steroids in Newborn Rats: A Sex-Specific Balance Between Allopregnanolone and Progesterone Receptors Experimental physiology · 2017
    2. Null Mutation of 5α-Reductase Type I Gene Alters Ethanol Consumption Patterns in a Sex-Dependent Manner Behavior Genetics · 2014
    3. Neonatal Finasteride Administration Alters Hippocampal α4 and δ GABAAR Subunits Expression and Behavioral Responses to Progesterone in Adult Rats The International Journal of Neuropsychopharmacology · 2013
    4. Alteration of Ethanol Drinking in Mice via Modulation of the GABAA Receptor with Ganaxolone, Finasteride, and Gaboxadol Alcoholism: Clinical and Experimental Research · 2011
    5. The Anxiolytic Effect of Pregnancy in Rats Is Reversed by Finasteride Pharmacology, Biochemistry and Behavior · 2006
    6. Anxiolytic Activity of Progesterone in Progesterone Receptor Knockout Mice Neuropharmacology · 2004