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research Inhibition of 5α-Reductase Activity in Late Pregnancy Decreases Gestational Length and Fecundity and Impairs Object Memory and Central Progestogen Milieu of Juvenile Rat Offspring

32 citations , September 2011 in “Journal of Neuroendocrinology”

Inhibiting 5α-reductase during late pregnancy shortens gestation, reduces litter size, and harms memory in rat offspring.

Early Postnatal Neuroactive Steroid Manipulation Differentially Affects Recognition Memory and Passive Avoidance Performance in Male Rats

research Early Postnatal Neuroactive Steroid Manipulation Differentially Affects Recognition Memory and Passive Avoidance Performance in Male Rats

2 citations , July 2020 in “Behavioural Brain Research”

Changing neuroactive steroids in baby male rats affects their memory and learning differently as they grow up.

Inhibition of 5α-Reductase Impairs Cognitive Performance, Alters Dendritic Morphology, and Increases Tau Phosphorylation in the Hippocampus of Male 3xTg-AD Mice

research Inhibition of 5α-Reductase Impairs Cognitive Performance, Alters Dendritic Morphology, and Increases Tau Phosphorylation in the Hippocampus of Male 3xTg-AD Mice

13 citations , January 2020 in “Neuroscience”

Blocking 5α-reductase can harm memory and brain structure, and increase harmful brain changes in male mice used for Alzheimer's disease research.

research Mucosal TLR5 Activation Controls Healthspan and Longevity

1 citations , January 2024 in “Nature communications”

Activating TLR5 in the gut can extend lifespan and improve health in aged mice.

research Androgens Protect Against Apolipoprotein E4-Induced Cognitive Deficits

182 citations , June 2002 in “Journal of Neuroscience”

Androgens can help prevent memory problems caused by apoE4.

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community Pyrilutamide ,the molecule’s true nature

in Research 302 upvotes 1 year ago

Pyrilutamide is a selective AR antagonist with a high binding affinity, making it effective in competing with DHT for androgen receptors. The 1% concentration is more effective than the 0.5%, but the latter may suffice for mild hair loss; the drug is considered a good option for those avoiding 5AR blockers due to side effects.

community I've had a FUE hair transplant in Turkey today. AMA.

in Transplants 16 upvotes 8 years ago

A 36-year-old male had a 3000-graft FUE hair transplant in Turkey, with 2000 grafts to the front and 1000 to the crown. Post-operation, he experienced nausea, dizziness, itching, and pain, but saw hair growth and plans to take pictures once redness subsides.

community Do you guys know anything about exosome stem cell injections? Results/risk?

in Research/Science 8 upvotes 10 months ago

Considering exosome stem cell injections for hair loss alongside minoxidil and finasteride. Some suggest trying dutasteride first due to its proven effectiveness.

community Upcoming treatment ideas in the future

in Research/Science 10 upvotes 1 year ago

Exploring future hair loss treatments, including immunosuppressants for hair transplants and hair cloning, with a focus on leveraging research from other medical fields. Current treatments like finasteride and minoxidil are effective for most, but there's a call for more funding and innovation in the hair loss industry.

community What now, friends? is it over?

in General 159 upvotes 1 week ago

The user has tried various hair loss treatments, including minoxidil, finasteride, ketoconazole, biotin spray, oral medications, and a Revian cap, but has not seen lasting improvement. They are considering stopping treatments and are frustrated with the lack of progress and the financial and emotional toll.

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