January 2026 in “Hormones and Behavior” In this study, researchers observed that reproductive experience in female rats altered fear memory and medial prefrontal cortex (mPFC) activity, with pregnant and parous rats showing impaired fear recall compared to nulliparous controls, highlighting the influence of pregnancy-related neurosteroids on cognitive function and brain activity.
5 citations
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January 2025 in “Science Advances” In this study, researchers observed that acute stress increased levels of the enzyme 5αR2 in the medial prefrontal cortex of male rats, affecting stress reactivity, but this effect was not seen in females.
53 citations
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October 2011 in “Psychoneuroendocrinology” Finasteride may help improve certain brain function issues linked to dopamine.
36 citations
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January 2018 in “Scientific reports” This study observed that dietary intake of glucoraphanin during juvenile and adolescent stages prevented cognitive deficits and abnormal gene expressions in the brain of adult offspring exposed to maternal immune activation, potentially implicating centrosome-related genes in the development of psychosis.
32 citations
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September 2011 in “Journal of Neuroendocrinology” In this study, inhibiting the formation of 5α-reduced steroids in pregnant rats shortened gestation time, reduced litter size, and impaired cognitive and neuroendocrine function in their juvenile offspring.