Effects of In Utero Exposure to Finasteride on Androgen-Dependent Reproductive Development in Male Rats

    May 2003 in “ Toxicological Sciences ”
    Christopher J. Bowman, Norman J. Barlow, Katie J. Turner … Paul M.D. Foster
    Studysummary This study found that prenatal exposure to finasteride in rats led to permanent changes in developmental endpoints like anogenital distance and nipple retention, which were predictive of further reproductive tract malformations.
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    Research cited in this study 4

    1. Critical Developmental Periods for Effects on Male Rat Genitalia Induced by Finasteride, a 5α-Reductase Inhibitor Toxicology and Applied Pharmacology · 1993
    2. Effects of Flutamide and Finasteride on Rat Testicular Descent Endocrinology · 1991
    3. External Genitalia Abnormalities in Male Rats Exposed In Utero to Finasteride, a 5α-Reductase Inhibitor Teratology · 1990
    4. Nipple Differentiation in Fetal Male Rats Treated with an Inhibitor of the Enzyme 5α-Reductase: Definition of a Selective Role for Dihydrotestosterone Endocrinology · 1986

    Related research 2

    1. Effects of In Utero Exposure to Finasteride on Androgen-Dependent Reproductive Development in Male Rats Toxicological Sciences · 2003
    2. Combination of an Antiandrogen and a 5α-Reductase Inhibitor: A Further Step Towards Total Androgen Blockade? Endocrinology · 1991