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This study found that prenatal exposure to finasteride in rats led to permanent changes in developmental endpoints like anogenital distance and nipple retention, which were predictive of further reproductive tract malformations.

In this study, male rats exposed in utero to low-dose chemical mixtures had permanent reproductive tract alterations, suggesting additive effects even at doses below individual adverse levels.

This study identified dose levels of selenium that can produce toxicity, noting that doses as low as 2-3 µg Se/kg bw/day can lead to adverse effects, and a human mortality study linked 300 µg/day consumption to increased death risk.

This study found that combining oral testosterone with dutasteride increased testosterone bioavailability in hypogonadal men while suppressing dihydrotestosterone levels over a 28-day period.

This study introduced Cadd4, a peptide-based degrader developed using computer-aided drug design, which effectively reduced PCSK9 levels and increased LDL receptor expression, resulting in decreased plasma cholesterol and LDL-C levels in hypercholesterolemic mice, without liver toxicity.