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GlossaryAnogenital Distance (AGD)

distance between the anus and genitals

Anogenital Distance (AGD) is the measurement from the anus to the base of the genitals. It is a marker of prenatal androgen exposure and is often used in medical and biological research to assess reproductive health and development. In males, a longer AGD is typically observed compared to females, and variations in AGD can be linked to certain health conditions and endocrine disruptions.

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research Assessment of Anogenital Distance as a Diagnostic Tool in Polycystic Ovary Syndrome

15 citations , October 2018 in “Reproductive Biomedicine Online”

Measuring the distance from the anus to the clitoris may moderately help diagnose polycystic ovary syndrome, especially in certain cases.

research Effects of In Utero Exposure to Finasteride on Androgen-Dependent Reproductive Development in Male Rats

118 citations , May 2003 in “Toxicological Sciences”

Exposure to finasteride in the womb caused lasting reproductive issues in male rats.

research Anogenital Distance as a Biomarker for Incomplete Masculinization: Molecular Mechanisms in the Perineum

January 2020 in “Research Portal Denmark”

A short male anogenital distance may indicate incomplete masculinization due to disrupted androgen action.

research Presence of Polycystic Ovary Syndrome Is Associated with Longer Anogenital Distance in Adult Mediterranean Women

42 citations , August 2017 in “Human Reproduction”

Women with polycystic ovary syndrome tend to have a longer distance between the clitoris and anus.

AGD1, A Class 1 ARF-GAP, Acts in Common Signaling Pathways with Phosphoinositide Metabolism and the Actin Cytoskeleton in Controlling Arabidopsis Root Hair Polarity

research AGD1, A Class 1 ARF-GAP, Acts in Common Signaling Pathways with Phosphoinositide Metabolism and the Actin Cytoskeleton in Controlling Arabidopsis Root Hair Polarity

56 citations , December 2011 in “The Plant Journal”

AGD1 is important for root hair development in Arabidopsis, working with phosphoinositide signaling and the actin cytoskeleton.

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community C’est terrible - at my wits end

in Female 450 upvotes 2 years ago

A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.