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GlossaryAnogenital Distance

distance between the anus and genitals

Anogenital Distance (AGD) is the measurement from the anus to the base of the genitals. It is a marker of prenatal androgen exposure and is often used in medical and biological research to assess reproductive health and development. In males, a longer AGD is typically observed compared to females, and variations in AGD can be linked to certain health conditions and endocrine disruptions.

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research Systematic Analyses of Murine Masculinization Processes Based on Genital Sex Differentiation Parameters

21 citations , December 2015 in “Development Growth & Differentiation”

DHT is crucial for urethral formation, and its disruption can affect masculinization and lead to hypospadias.

research Assessment of Anogenital Distance as a Diagnostic Tool in Polycystic Ovary Syndrome

15 citations , October 2018 in “Reproductive Biomedicine Online”

Measuring the distance from the anus to the clitoris may moderately help diagnose polycystic ovary syndrome, especially in certain cases.

research Effects of In Utero Exposure to Finasteride on Androgen-Dependent Reproductive Development in Male Rats

118 citations , May 2003 in “Toxicological Sciences”

Exposure to finasteride in the womb caused lasting reproductive issues in male rats.

research Anogenital Distance as a Biomarker for Incomplete Masculinization: Molecular Mechanisms in the Perineum

January 2020 in “Research Portal Denmark”

A short male anogenital distance may indicate incomplete masculinization due to disrupted androgen action.

research Distinct Transcriptional Profiles of the Female, Male, and Finasteride-Induced Feminized Male Anogenital Region in Rat Fetuses

10 citations , February 2019 in “Toxicological Sciences”

Finasteride exposure affects gene expression and anogenital distance in male rat fetuses.

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