5α-Reductases in Human Physiology: An Unfolding Story

    July 2012 in “ Endocrine Practice ”
    Abdulmaged M. Traish
    Studysummary This review highlights the need for a deeper understanding of 5alpha-reductases and neuroactive steroids to reduce potential adverse effects of 5alpha-reductase inhibitors used for conditions like benign prostatic hyperplasia and androgenic alopecia, but reports no new clinical results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 20

    1. Incomplete Recovery of Erectile Function in Rats After Discontinuation of Dual 5-Alpha Reductase Inhibitor Therapy The Journal of Sexual Medicine · 2012
    2. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011
    3. T Cell–Mediated Acute Localized Exanthematous Pustulosis Caused by Finasteride The Journal of Allergy and Clinical Immunology · 2011
    4. Finasteride-Induced Pseudoporphyria Archives of Dermatology · 2011
    5. Finasteride-Associated Cataract And Intraoperative Floppy-Iris Syndrome Journal of Cataract and Refractive Surgery · 2011
    6. Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011
    7. Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010
    8. SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder Cell · 2010
    9. Finasteride Treatment Inhibits Adult Hippocampal Neurogenesis in Male Mice Pharmacopsychiatry · 2010
    10. Neurosteroids Involved in Regulating Inhibition in the Inferior Colliculus Journal of Neurophysiology · 2006
    11. Neurosteroids, Neuroactive Steroids, and Symptoms of Affective Disorders Pharmacology, Biochemistry and Behavior · 2006
    12. Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABA A Receptor Function and Seizure Susceptibility Journal of Neuroscience · 2002
    13. 5α-Reductase Activity in the Prostate Urology · 2001
    14. Cloning, Expression, and Characterization of Rhesus Macaque Types 1 and 2 5alpha-Reductase: Evidence for Mechanism-Based Inhibition by Finasteride The Journal of Steroid Biochemistry and Molecular Biology · 1998
    15. The Effect of Finasteride on the Risk of Acute Urinary Retention and the Need for Surgical Treatment Among Men with Benign Prostatic Hyperplasia The New England Journal of Medicine · 1998
    16. Inhibition of Rat Alpha-Reductases by Finasteride: Evidence for Isozyme Differences in the Mechanism of Inhibition The Journal of Steroid Biochemistry and Molecular Biology · 1997
    17. Effects of Finasteride, a Type 2 5-Alpha Reductase Inhibitor, on Fetal Development in the Rhesus Monkey (Macaca Mulatta) Teratology · 1997
    18. Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP-Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor Journal of the American Chemical Society · 1996
    19. Age-Related Changes in Brain and Pituitary 5α-Reductase with Finasteride (Proscar) Treatment Neurobiology of Aging · 1995
    20. Finasteride: A Slow-Binding 5-Alpha-Reductase Inhibitor Biochemistry · 1993