5α-Reductases in Human Physiology: An Unfolding Story
November 2012
in “
Endocrine Practice
”
TLDR Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.
The 2012 study "5α-Reductases in Human Physiology: An Unfolding Story" explored the function of 5α-reductases, enzymes that convert hormones into a subclass of neuroactive steroid hormones. These hormones have various physiological roles, including sexual differentiation, neuroprotection, memory enhancement, anxiety regulation, sleep, and stress. The study also discussed the use of 5α-reductase inhibitors in treating conditions like benign prostatic hyperplasia and androgenetic alopecia. However, it stressed the need for a deeper understanding of 5α-reductases and neuroactive steroids to reduce potential side effects of these inhibitors, particularly on the central nervous system. The study was based on a literature review from 1970 to 2011.
