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    Glossary Neurosteroids

    steroids produced in the brain that affect neuron function

    Neurosteroids, also known as neuroactive steroids, are a class of steroids synthesized in the brain and nervous system. They play a crucial role in modulating neuronal activity, influencing mood, stress response, and cognitive functions by interacting with neurotransmitter receptors such as GABA and NMDA.

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    Research 10 of 408

    1. Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABA<sub>A</sub>Receptor Function and Seizure Susceptibility Journal of Neuroscience · 2002 · 269 citations
    2. Neurosteroidogenesis Is Required for the Physiological Response to Stress: Role of Neurosteroid-Sensitive GABA<sub>A</sub>Receptors Journal of Neuroscience · 2011 · 248 citations
    3. Neurosteroid Synthesis-Mediated Regulation of GABA<sub>A</sub>Receptors: Relevance to the Ovarian Cycle and Stress Journal of Neuroscience · 2007 · 238 citations
    4. Anticonvulsant Activity of Progesterone and Neurosteroids in Progesterone Receptor Knockout Mice Journal of Pharmacology and Experimental Therapeutics · 2004 · 180 citations
    5. Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3α-androstanediol and 17β-estradiol Neuroscience · 2004 · 136 citations
    6. Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research Journal of Neuroendocrinology · 2015 · 123 citations
    7. Inhibition of neurosteroid synthesis increases asphyxia-induced brain injury in the late gestation fetal sheep Neuroscience · 2007 · 100 citations
    8. Midazolam Inhibits Hippocampal Long-Term Potentiation and Learning through Dual Central and Peripheral Benzodiazepine Receptor Activation and Neurosteroidogenesis Journal of Neuroscience · 2010 · 97 citations
    9. Production of 5α-Reduced Neurosteroids Is Developmentally Regulated and Shapes GABA<sub>A</sub>Miniature IPSCs in Lamina II of the Spinal Cord Journal of Neuroscience · 2004 · 88 citations
    10. The role of pregnane neurosteroids in ethanol withdrawal: behavioral genetic approaches Pharmacology & Therapeutics · 2004 · 83 citations
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    Community 10 of 30

    1. Finasteride, Neurosteroids, and Neuroplasticity - have you noticed cognitive shifts or have you continued growing? Community · 4 Jun 2026
    2. Finasteride - impact on Neurosteroids, which yes, \are important and not a garbage hormone Reddit · 24 Jul 2025
    3. What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas Reddit · 25 Jun 2024
    4. Androsterone as a Neurosteroid Replacement Strategy for 5α-Reductase Inhibitor–Associated Sexual and Affective Dysfunction Reddit · 15 Jul 2026
    5. Experienced Sleep Paralysis for the First Time After Starting Finasteride Community · 1 Feb 2026
    6. 22M started fin/min/dermaroller again after stopping for almost 2 years (2months progress) Reddit · 15 Sept 2025
    7. Low cortisol it is due the fin Reddit · 19 Jul 2025
    8. 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that? Reddit · 3 Oct 2024
    9. How to Keep Your Hair on Steroids Reddit · 10 Sept 2024
    10. Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral. Reddit · 20 Jul 2024
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