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GlossaryNeurosteroids

steroids produced in the brain that affect neuron function

Neurosteroids, also known as neuroactive steroids, are a class of steroids synthesized in the brain and nervous system. They play a crucial role in modulating neuronal activity, influencing mood, stress response, and cognitive functions by interacting with neurotransmitter receptors such as GABA and NMDA.

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community Proof that finasteride messes with neurosteroids

in Research/Science 230 upvotes 5 months ago

Finasteride can impact neurosteroids, potentially causing depression and other side effects in some users. Despite these concerns, many continue using it for hair loss, with some switching to topical applications to mitigate side effects.

community What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas

in Research/Science 21 upvotes 5 months ago

Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.

community A systematic bro-science review of DHT, 5AR, neurosteroids, sexual health and 5AR inhibitors

in Research/Science 37 upvotes 2 years ago

Hair loss treatments, specifically 5AR inhibitors, can impact neurosteroids and sexual health. The effects of topical fin/dut on tissue-specific DHT levels are unclear.

community Insomnia and Finasteride

in Finasteride/Dutasteride 6 upvotes 3 years ago

A user reports experiencing insomnia as a side effect of taking finasteride for hair loss, which takes 1 to 2 hours to fall asleep and results in only about 5 hours of sleep per night. They suspect the cause is related to the downregulation of neurosteroids due to finasteride.

community Anyone here holding out for Breezula?

in Treatment 6 upvotes 4 years ago

The conversation is about individuals considering waiting for Breezula to treat hair loss instead of using Finasteride due to concerns about side effects. Some are opting for Finasteride now, while others are wary of its impact on neurosteroids.

community Progressive insomnia (treatment-resistant) due to Finasteride

in Finasteride/Dutasteride 7 upvotes 2 years ago

A medical student experienced hair loss slowing with Finasteride but developed severe, treatment-resistant insomnia. They tried various medications with little effect, suspecting Post-Finasteride Syndrome, and others suggested the insomnia might be linked to Finasteride's impact on neurosteroids.

community The Battle of Norwood (2024) | Dut 0.5 mg ED + Oral Min 5 mg ED

in Progress Pictures 516 upvotes 1 month ago

The conversation discusses hair regrowth using dutasteride and oral minoxidil, with the user reporting significant improvement in hair volume after combining these treatments. Some side effects mentioned include changes in libido and increased facial hair, but overall, the user is satisfied with the results.

community My kid secretly took my avodart what should i do

in Is this regrowth? 42 upvotes 2 months ago

A child accidentally took Avodart, leading to concerns about DHT suppression and its effects. Users humorously discuss potential consequences and treatments like DHT injections and topical solutions.

community Finasteride and Its Effects on Cognition: Where's the Science?

in Research/Science 26 upvotes 4 years ago

The user shared their experience with hair loss treatments, including low-dose minoxidil, finasteride, and essential oils, and expressed concerns about the cognitive side effects of finasteride. They are seeking more information on how finasteride may affect cognition and are considering whether to continue or stop the treatment.

community The safest way to use finasteride - my research

in Finasteride 24 upvotes 7 years ago

The post discusses microdosing finasteride to minimize side effects while treating hair loss. The user also mentions using minoxidil, biotin, and ketoconazole.

community Oral or topical finasteride? .

in Chat 12 upvotes 4 months ago

A user is deciding between oral and topical finasteride for hair loss, noting oral finasteride's ease of use but broader effects. Another user simply recommends oral finasteride.

community The Bad Ending: You Lose Finasteride

in Satire 129 upvotes 4 months ago

The conversation humorously discusses the effects of stopping finasteride for two years, with users joking about hair loss and embracing baldness. Treatments mentioned include finasteride.

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 138 upvotes 5 months ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

community Tired of playing this game on hard mode? (not click bait).

in Treatment 7 months ago

Hair loss can be linked to low testosterone, affecting DHT and estrogen levels. Treatments discussed include increasing testosterone, using Finasteride, and applying estrogen cream.

community Sulforaphane Topical to Degrade DHT - For People Who Want to Try the Theory that Explains Everything

in Treatment 38 upvotes 3 years ago

A user suggests making a potent sulforaphane topical to degrade DHT and promote hair growth. Another user notes that sulforaphane's low molecular weight might also lower systemic DHT.

community ecklonia cava?

in Question 4 upvotes 5 years ago

The conversation discusses using ecklonia cava as a natural alternative to finasteride for hair loss. Users share their experiences and opinions on its effectiveness.

community How come Dut doesn’t cause more brain problems than fin if it inhibits Type 1 5AR?

in Finasteride/Dutasteride 22 upvotes 5 months ago

Dutasteride and finasteride have similar risk profiles despite Dutasteride blocking more types of 5AR in the brain. Some users report no mood issues with either drug, and it is suggested that Dutasteride's larger molecular size may limit its ability to cross the blood-brain barrier.

community Is it possible for Dutasteride to make one mentally slow?

in Chat 22 upvotes 6 months ago

Dutasteride may cause mental fog, vision blurriness, and sleep issues. Users suggest trying topical versions of the drug to mitigate side effects.

community 6 months of using Hims finasteride and minoxidil spray!

in Progress Pictures 690 upvotes 9 months ago

A user shared their positive 6-month experience using Hims finasteride and minoxidil spray for hair loss, with others discussing the effectiveness and side effects of topical treatments. Instructions on how to use the spray were also provided.

community 7.5 months and fin, time for dut?

in Finasteride/Dutasteride 12 upvotes 10 months ago

The user has been using 1mg finasteride, 2% ketoconazole shampoo, vitamins, and growth shampoo for 7.5 months to treat hair loss and is considering switching to 0.5 mg dutasteride due to slight recession and persistent symptoms. Another user commented that the user's temples appear to have improved, especially in the latest photo.

community 4600 - result 9 month - Dr. Carman

in Progress Pictures 253 upvotes 10 months ago

A user shared their 9-month post-hair transplant results with 4600 grafts, using only Nourkin hair vitamins, Vitamin D, and B12, and expressed satisfaction. The replies debated the necessity of medications like finasteride and minoxidil for maintaining hair health.

community Can RU58841 stop hairloss for a long time?

in Research/Science 9 upvotes 1 year ago

A user is considering using RU58841 to treat hair loss and asks if it can be effective for 4-5 years. Some suggest starting with a lower concentration and debate the safety of RU58841 compared to approved drugs like finasteride.

community What do we actually know about HMI-115?

in Chat 16 upvotes 1 year ago

The post and conversation are about HMI-115, a potential treatment for hair loss. The conclusion is that HMI-115 is not a 5ar-inhibitor and is instead a prolactin receptor inhibitor. Some users are skeptical about its effectiveness and believe that baldness will still be a problem in the future.

community Update to fin 0.25 mg, 4x/week

in Progress Pictures 64 upvotes 1 year ago

User reported initial hair regrowth with 0.25 mg finasteride taken four times a week, experiencing a second shedding phase, and no side effects. They also mentioned using RU58841 without success and plan to stop after a year.

community PCOS female who posted before; saw Endo today. prescribed spironolactone and minox 5%

in Update 1 upvotes 1 year ago

PCOS female visited doctor for hair loss concerns, prescribed spironolactone and minox 5%. Doctor advised against finasteride or dutasteride, user considering self-medication with dutasteride.

community starting out Nizoral shampoo, do I buy more bottles after I finish or switch back to traditional shampoo?

in Ketoconazole 62 upvotes 2 years ago

Using Nizoral shampoo intermittently and reassessing scalp condition after each bottle, potentially adding in other tools to target seb derm, and alternating between Pura D'Or and Nizoral for a healthy and clean scalp.

community 1.5 years of Fin, switch 3 months ago to Dut, with 5 moths of Min too

in Progress Pictures 104 upvotes 2 years ago

User switched from Fin to Dut for better hair loss results, using 0.5mg Dut and 1ml Min daily. Some discuss potential side effects and benefits of Dut compared to Fin.

community Pyrilutamide US Phase 2 Trial?

in Research/Science 27 upvotes 2 years ago

The Phase 2 trial for Pyrilutamide in the US, which started a year after the China trials, and inquiring about any available information on when it will finish. Treatments discussed include Minoxidil, Finasteride, and RU58841.

community A 5 month difference on the BIG 4 . Oral minoxidil plus Dutasteride results.

in Progress Pictures 92 upvotes 2 years ago

Ramsko1's experience with a hair loss regimen of oral minoxidil, dutasteride, ketoconazole cream, and dermarolling, which they started after considering taking their own life due to hair loss. Other users replied to offer support and ask questions about specific treatments.

community maybe some of you need to hear this

in Chat 326 upvotes 2 years ago

Coping with hair loss, the effects of finasteride and minoxidil, and strategies for maintaining self-esteem while experiencing hair loss.