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GlossaryNeurosteroidogenesis

process of producing brain steroids that affect mood and cognition

Neurosteroidogenesis is the process by which the brain and nervous system produce neurosteroids, which are a type of steroid hormone. These neurosteroids play crucial roles in modulating brain function, influencing mood, stress response, and cognitive abilities.

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research Neurosteroidogenesis Is Required for the Physiological Response to Stress: Role of Neurosteroid-Sensitive GABA-A Receptors

248 citations , December 2011 in “Journal of Neuroscience”

Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research

research Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research

123 citations , December 2015 in “Journal of Neuroendocrinology”

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

research Ethanol Enhances Neurosteroidogenesis in Hippocampal Pyramidal Neurons by Paradoxical NMDA Receptor Activation

82 citations , July 2011 in “Journal of Neuroscience”

Ethanol boosts brain steroid production by activating NMDA receptors, affecting memory formation.

research Neurosteroidogenesis and Exploratory Responses in Rodents

1 citations , January 2014 in “PubMed”

research Nucleus-Specific Modulation of Phasic and Tonic Inhibition by Endogenous Neurosteroidogenesis in the Murine Thalamus

November 2019 in “Synapse”

Brain-made chemicals can control nerve cell function differently in various parts of a mouse's brain, which may help us understand neurological conditions.

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community No, Finasteride as a treatment for MPB was not an "accident"

in Research/Science 106 upvotes 4 years ago

Finasteride was intentionally developed to treat BPH and later approved for male pattern baldness (MPB) due to its 5AR inhibition effects. The delay in MPB approval was due to concerns about off-label use for female hirsutism and the prioritization of treating a more debilitating condition.