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GlossaryNeurosteroidogenesis

process of producing brain steroids that affect mood and cognition

Neurosteroidogenesis is the process by which the brain and nervous system produce neurosteroids, which are a type of steroid hormone. These neurosteroids play crucial roles in modulating brain function, influencing mood, stress response, and cognitive abilities.

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research Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research

123 citations, December 2015 in “Journal of Neuroendocrinology”

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

research Nucleus-Specific Modulation of Phasic and Tonic Inhibition by Endogenous Neurosteroidogenesis in the Murine Thalamus

November 2019 in “Synapse”

Brain-made chemicals can control nerve cell function differently in various parts of a mouse's brain, which may help us understand neurological conditions.

research Sex Differences in Steroid Levels and Steroidogenesis in the Nervous System: Physiopathological Role

35 citations, November 2019 in “Frontiers in Neuroendocrinology”

Men and women have different levels and production of brain steroids, which may affect their risk for certain brain disorders.

research Divergent Neuroactive Steroid Responses to Stress and Ethanol in Rat and Mouse Strains: Relevance for Human Studies

34 citations, April 2014 in “Psychopharmacology”

Stress and alcohol affect brain chemicals differently in rats, mice, and humans, influenced by genetic differences.

research Witnessed Trauma Exposure Induces Fear in Mice Through a Reduction in Endogenous Neurosteroid Synthesis

July 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Seeing trauma causes fear in mice by lowering their natural fear-reducing hormones.

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community No, Finasteride as a treatment for MPB was not an "accident"

in Research/Science 105 upvotes 3 years ago

Finasteride was intentionally developed to treat BPH and later approved for male pattern baldness (MPB) due to its 5AR inhibition effects. The delay in MPB approval was due to concerns about off-label use for female hirsutism and the prioritization of treating a more debilitating condition.