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    Glossary Neurosteroidogenesis

    process of producing brain steroids that affect mood and cognition

    Neurosteroidogenesis is the process by which the brain and nervous system produce neurosteroids, which are a type of steroid hormone. These neurosteroids play crucial roles in modulating brain function, influencing mood, stress response, and cognitive abilities.

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    Research 30 of 82

    1. Neurosteroidogenesis Is Required for the Physiological Response to Stress: Role of Neurosteroid-Sensitive GABA<sub>A</sub>Receptors Journal of Neuroscience · 2011 · 248 citations
    2. Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research Journal of Neuroendocrinology · 2015 · 123 citations
    3. Midazolam Inhibits Hippocampal Long-Term Potentiation and Learning through Dual Central and Peripheral Benzodiazepine Receptor Activation and Neurosteroidogenesis Journal of Neuroscience · 2010 · 97 citations
    4. Ethanol Enhances Neurosteroidogenesis in Hippocampal Pyramidal Neurons by Paradoxical NMDA Receptor Activation Journal of Neuroscience · 2011 · 82 citations
    5. [Neurosteroidogenesis and exploratory responses in rodents]. PubMed · 2014 · 1 citations
    6. Nucleus‐specific modulation of phasic and tonic inhibition by endogenous neurosteroidogenesis in the murine thalamus Synapse · 2019
    7. Midazolam Ameliorates the Behavior Deficits of a Rat Posttraumatic Stress Disorder Model through Dual 18 kDa Translocator Protein and Central Benzodiazepine Receptor and Neurosteroidogenesis PLoS ONE · 2014 · 56 citations
    8. Production of 5α-Reduced Neurosteroids Is Developmentally Regulated and Shapes GABA<sub>A</sub>Miniature IPSCs in Lamina II of the Spinal Cord Journal of Neuroscience · 2004 · 88 citations
    9. Palmitoylethanolamide Stimulation Induces Allopregnanolone Synthesis in C6 Cells and Primary Astrocytes: Involvement of Peroxisome-Proliferator Activated Receptor-α Journal of Neuroendocrinology · 2011 · 52 citations
    10. Sex differences in steroid levels and steroidogenesis in the nervous system: Physiopathological role Frontiers in Neuroendocrinology · 2019 · 35 citations
    11. Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: relevance for human studies Psychopharmacology · 2014 · 34 citations
    12. Witnessed trauma exposure induces fear in mice through a reduction in endogenous neurosteroid synthesis Journal of Neuroendocrinology · 2024 · 7 citations
    13. Witnessed trauma exposure induces fear in mice through a reduction in endogenous neurosteroid synthesis bioRxiv (Cold Spring Harbor Laboratory) · 2023
    14. 2‐Deoxy‐d‐glucose enhances tonic inhibition through the neurosteroid‐mediated activation of extrasynaptic GABA<sub>A</sub> receptors Epilepsia · 2016 · 44 citations
    15. 5α-Reductase Isoenzymes: From Neurosteroid Biosynthesis to Neuropsychiatric Outcomes NeuroSci · 2026
    16. Implication of allopregnanolone in the antinociceptive effect of N -palmitoylethanolamide in acute or persistent pain Pain · 2011 · 61 citations
    17. Mitochondrial dysfunction in diabetic neuropathy may be involved in the development of neuropathic pain via a reduction in neurosteroid synthesis F1000Research · 2017 · 4 citations
    18. Adverse Side Effects of 5α‐Reductase Inhibitors Therapy: Persistent Diminished Libido and Erectile Dysfunction and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010 · 223 citations
    19. Relationships between cerebrospinal fluid GABAergic neurosteroid levels and symptom severity in men with PTSD Psychoneuroendocrinology · 2018 · 59 citations
    20. Expression and roles of steroidogenic acute regulatory (StAR) protein in ‘non-classical’, extra-adrenal and extra-gonadal cells and tissues Molecular and Cellular Endocrinology · 2013 · 48 citations
    21. Post-finasteride syndrome: An emerging clinical problem Neurobiology of Stress · 2019 · 26 citations
    22. Targeting neurosteroid synthesis as a therapy for schizophrenia-related alterations induced by early psychosocial stress Schizophrenia Research · 2015 · 24 citations
    23. Relating neurosteroid modulation of inhibitory neurotransmission to behaviour Journal of Neuroendocrinology · 2021 · 18 citations
    24. Physiopathological role of the enzymatic complex 5α-reductase and 3α/β-hydroxysteroid oxidoreductase in the generation of progesterone and testosterone neuroactive metabolites Frontiers in Neuroendocrinology · 2020 · 18 citations
    25. Post-finasteride syndrome Anais Brasileiros De Dermatologia · 2020 · 15 citations
    26. Steroid 5α-reductase 2 deficiency leads to reduced dominance-related and impulse-control behaviors Psychoneuroendocrinology · 2018 · 14 citations
    27. Exploring the neural mechanisms of finasteride: a proteomic analysis in the nucleus accumbens Psychoneuroendocrinology · 2016 · 14 citations
    28. Inhibition of 5α Reductase Impairs Cognitive Performance, Alters Dendritic Morphology and Increases Tau Phosphorylation in the Hippocampus of Male 3xTg-AD Mice Neuroscience · 2020 · 13 citations
    29. Effects of non-contingent cocaine on 3alpha-androstanediol. I. Disruption of male sexual behavior Physiology & Behavior · 2019 · 4 citations
    30. How Does Altered Metabolism Lead to Seizure Control? Partially Filling the Knowledge Gap Epilepsy Currents · 2010 · 3 citations