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    Divergent Neuroactive Steroid Responses to Stress and Ethanol in Rat and Mouse Strains: Relevance for Human Studies

    April 2014 in “ Psychopharmacology ”
    Patrizia Porcu, A. Leslie Morrow
    Studysummary This review discusses the pharmacological properties and physiological regulation of neuroactive steroids, focusing on their varied responses to stress and ethanol in rats, mice, and humans, but it reports no new findings.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 11

    1. Dutasteride Reduces Alcohol’s Sedative Effects in Men in a Human Laboratory Setting and Reduces Drinking in the Natural Environment Psychopharmacology · 2014
    2. Decreased Alcohol Consumption Among Former Male Users of Finasteride with Persistent Sexual Side Effects: A Preliminary Report Alcoholism: Clinical and Experimental Research · 2013
    3. Neurosteroidogenesis Is Required for the Physiological Response to Stress: Role of Neurosteroid-Sensitive GABA-A Receptors Journal of Neuroscience · 2011
    4. Ethanol Enhances Neurosteroidogenesis in Hippocampal Pyramidal Neurons by Paradoxical NMDA Receptor Activation Journal of Neuroscience · 2011
    5. Midazolam Inhibits Hippocampal Long-Term Potentiation and Learning Through Dual Central and Peripheral Benzodiazepine Receptor Activation and Neurosteroidogenesis Journal of Neuroscience · 2010
    6. Neurosteroids Involved in Regulating Inhibition in the Inferior Colliculus Journal of Neurophysiology · 2006
    7. GABRA2 Alleles Moderate the Subjective Effects of Alcohol, Which Are Attenuated by Finasteride Neuropsychopharmacology · 2005
    8. Ethanol-Induced Elevation of 3α-Hydroxy-5α-Pregnan-20-One Does Not Modulate Motor Incoordination in Rats Alcoholism Clinical and Experimental Research · 2004
    9. The Role of Pregnane Neurosteroids in Ethanol Withdrawal: Behavioral Genetic Approaches Pharmacology & Therapeutics · 2004
    10. Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABA A Receptor Function and Seizure Susceptibility Journal of Neuroscience · 2002
    11. Inhibition of Rat Alpha-Reductases by Finasteride: Evidence for Isozyme Differences in the Mechanism of Inhibition The Journal of Steroid Biochemistry and Molecular Biology · 1997