research Human Hair Follicles Display a Functional Equivalent of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Synthesize Cortisol
Human hair follicles can produce cortisol like the body's stress response system.
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5 / 476 resultsresearch Maternal Influence on Child HPA Axis: A Prospective Study of Cortisol Levels in Hair
Maternal stress during pregnancy affects a child's stress levels.
research The Human Hair Follicle Has Established a Fully Functional Peripheral Equivalent of the Hypothalamic-Pituitary-Adrenal Axis (HPA)
Human hair follicles can produce stress hormones like the body's main stress response system.
research Localized Alopecia and Suppression of Hypothalamic-Pituitary-Adrenal Axis in Dogs Following Treatment with Difluprednate 0.05% Ophthalmic Emulsion
Long-term use of difluprednate eye drops in dogs can lead to hair loss and hormone imbalance.
research HPA Axis Variation and ACEs: Childhood Sexual Trauma Is Associated With Lower Hair Cortisol in Adulthood
Childhood sexual trauma, especially between ages 5-7, is linked to lower cortisol levels in adult hair, suggesting long-term stress response changes.
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5 / 26 resultscommunity EMA is re-examining Winlevi (clascoterone at lower concentration)
Clascoterone in Winlevi, a topical AR antagonist, is being re-examined due to concerns about HPA axis suppression in adolescents, but it's unlikely to be banned for adult use in androgenetic alopecia (AGA). The European Medicines Agency recommended refusing Winlevi for acne vulgaris, but this may not affect Breezula's approval for AGA.
community There’s actually a quite good chance that next year, we might see a new treatment get FDA approval for the first time in nearly three decades.
Breezula, a potential new hair loss treatment, may receive FDA approval soon, but it is expected to be a weaker alternative to finasteride and minoxidil. Concerns include its twice-daily application and possible side effects like HPA axis suppression.
community Is hydrocortisone that bad for your scalp?
Hydrocortisone is not recommended for long-term use on the scalp due to potential side effects like thinning and steroid-related issues. Alternatives like foam minoxidil or oral minoxidil are suggested, though foam may be less effective.
community Mechanism of action of alfatradiol (17 alpha estradiol)
The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.
community Anyone used CB-03-01 (clascoterone), is it worth it, too risky??
The user experienced side effects from low-dose topical finasteride and is considering using clascoterone (CB-03-01) despite concerns about its risks and cost. They seek advice on its effectiveness and potential side effects compared to other treatments like alfatradiol and fluridil.