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    Witnessed Trauma Exposure Induces Fear in Mice Through a Reduction in Endogenous Neurosteroid Synthesis

    July 2023 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Aidan Evans‐Strong, Najah Walton, Adrian Roper … Jamie Maguire

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary In this study, researchers found that both direct and witnessed trauma in mice were linked to lower levels of the neurosteroid allopregnanolone, and that boosting neurosteroidogenesis may alleviate PTSD-like symptoms, suggesting potential treatment strategies for PTSD stemming from either trauma type.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 18

    1. Suicidal Risk Associated With Finasteride Versus Dutasteride Among Men Treated for Benign Prostatic Hyperplasia: Nationwide Cohort Study Scientific Reports · 2023
    2. Post-Finasteride Syndrome: A Surmountable Challenge for Clinicians Fertility and Sterility · 2020
    3. Post-Finasteride Syndrome: An Emerging Clinical Problem Neurobiology of Stress · 2019
    4. The Steroidogenesis Inhibitor Finasteride Reduces the Response to Both Stressful and Rewarding Stimuli Biomolecules · 2019
    5. Repeated Finasteride Administration Induces Depression-Like Behavior in Adult Male Rats Behavioural Brain Research · 2019
    6. Relationships Between Cerebrospinal Fluid GABAergic Neurosteroid Levels and Symptom Severity in Men with PTSD Psychoneuroendocrinology · 2018
    7. Treatment of Male Rats with Finasteride, an Inhibitor of 5alpha-Reductase Enzyme, Induces Long-Lasting Effects on Depressive-Like Behavior, Hippocampal Neurogenesis, Neuroinflammation, and Gut Microbiota Composition Psychoneuroendocrinology · 2018
    8. Post-Finasteride Syndrome and Post-SSRI Sexual Dysfunction: Two Sides of the Same Coin? Endocrine · 2018
    9. Research Brief: Self-Reports of Persistent Antiandrogenic, Estrogenic, Physical, and Psychological Effects of Finasteride Usage Among Men American Journal of Men's Health · 2018
    10. A Comment on the Post-Finasteride Syndrome International Journal of Trichology · 2018
    11. Association of Suicidality and Depression With 5α-Reductase Inhibitors JAMA Internal Medicine · 2017
    12. Adverse Effects of 5α-Reductase Inhibitors: What Do We Know, Don't Know, and Need to Know? Reviews in Endocrine and Metabolic Disorders · 2015
    13. Sex Dependent Influence of a Functional Polymorphism in Steroid 5-Alpha-Reductase Type 2 (SRD5A2) on Post-Traumatic Stress Symptoms American Journal of Medical Genetics Part B Neuropsychiatric Genetics · 2013
    14. Depressive Symptoms and Suicidal Thoughts Among Former Users of Finasteride With Persistent Sexual Side Effects The Journal of Clinical Psychiatry · 2012
    15. Influence of Dosing Time on the Efficacy and Safety of Finasteride in Rats Journal of Pharmacology and Experimental Therapeutics · 2011
    16. Neurosteroid Synthesis-Mediated Regulation of GABA A Receptors: Relevance to the Ovarian Cycle and Stress Journal of Neuroscience · 2007
    17. Finasteride Induced Depression: A Prospective Study BMC clinical pharmacology · 2006
    18. Depression Related to Finasteride Administration for Androgenetic Alopecia Journal of Dermatology · 2002