Suicidal Risk Associated With Finasteride Versus Dutasteride Among Men Treated for Benign Prostatic Hyperplasia: Nationwide Cohort Study

    March 2023 in “ Scientific Reports ”
    Moussa Laanani, Alain Weill, Fabrice Jollant, Mahmoud Zureik, R. Dray‐Spira
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    TLDR Finasteride may increase the risk of suicide or severe self-harm in men with mood disorders but not in the general population.
    The study analyzed data from 287,363 men aged 50 years or older treated with either finasteride or dutasteride for benign prostatic hyperplasia (BPH) in France between 2012 and 2016. The results showed no increased risk of suicide or self-harm hospitalization in the general population with finasteride compared to dutasteride. However, among patients with a history of mood disorders, finasteride was associated with an increased risk of suicide or severe self-harm. The study concluded that while finasteride alone is unlikely to facilitate a suicidal act, it may trigger a suicidal act in those who are already in a fragile mental state or at risk of being in such a state. These results were based on a low number of events and should be interpreted with caution. Further research is needed to confirm these findings and to investigate the potential risk for younger men treated with low-dose finasteride for androgenetic alopecia.
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      in Research/Science  11 upvotes 8 months ago
      Finasteride and Dutasteride do not cause depression or "Post Finasteride Syndrome," with concerns often linked to the nocebo effect and preexisting mental health issues. The EU is unlikely to ban these drugs, but access may become more restricted due to ongoing debates.

      community Why does finasteride stop working?

      in Finasteride/Dutasteride  26 upvotes 10 months ago
      Finasteride may seem less effective over time due to increased DHT sensitivity or aging, but it still suppresses DHT. Switching to dutasteride offers stronger DHT suppression but may increase estrogen levels.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

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      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

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