Suicidal Risk Associated With Finasteride Versus Dutasteride Among Men Treated for Benign Prostatic Hyperplasia: Nationwide Cohort Study

    March 2023 in “ Scientific Reports ”
    Moussa Laanani, Alain Weill, Fabrice Jollant … R. Dray‐Spira
    Studysummary This cohort study found no overall increased risk of suicidal behaviors with finasteride versus dutasteride in men aged 50 and older, but suggested potential risk for those with a history of mood disorders.
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    Research cited in this study 34

    1. Rare and Common Genetic Determinants of Metabolic Individuality and Their Effects on Human Health Nature Medicine · 2022
    2. Further Studies of Effects of Finasteride on Mood and Suicidal Risk Journal of Clinical Psychopharmacology · 2021
    3. The Connection of 5-Alpha Reductase Inhibitors to the Development of Depression Biomedicine & Pharmacotherapy · 2021
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    5. Use of High-Dose Cyproterone Acetate and Risk of Intracranial Meningioma in Women: Cohort Study BMJ · 2021
    6. Investigation of Suicidality and Psychological Adverse Events in Patients Treated With Finasteride JAMA Dermatology · 2020
    7. Finasteride and Suicide: A Postmarketing Case Series Dermatology · 2020
    8. Post-Finasteride Syndrome BMJ · 2019
    9. Repeated Finasteride Administration Induces Depression-Like Behavior in Adult Male Rats Behavioural Brain Research · 2019
    10. Quality of Life Assessment in Patients with Androgenetic Alopecia International Journal of Trichology · 2019
    11. Efficacy and Safety of 5 Alpha-Reductase Inhibitor Monotherapy in Patients with Benign Prostatic Hyperplasia: A Meta-Analysis PLOS ONE · 2018
    12. Treatment of Male Rats with Finasteride, an Inhibitor of 5alpha-Reductase Enzyme, Induces Long-Lasting Effects on Depressive-Like Behavior, Hippocampal Neurogenesis, Neuroinflammation, and Gut Microbiota Composition Psychoneuroendocrinology · 2018
    13. A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Postfinasteride Syndrome Urology · 2018
    14. The 5α-Reductase Inhibitor Finasteride Increases Suicide-Related Aggressive Behaviors and Blocks Clozapine-Induced Beneficial Effects in an Animal Model of Schizophrenia Physiology & Behavior · 2018
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    16. Association of Suicidality and Depression With 5α-Reductase Inhibitors JAMA Internal Medicine · 2017
    17. Persistent Erectile Dysfunction in Men Exposed to 5α-Reductase Inhibitors, Finasteride, or Dutasteride PeerJ · 2017
    18. Finasteride 1 mg in Alopecia: Sexual Dysfunction, Suicidal Ideation. Providing Balanced Information to Male Patients Is Key. PubMed · 2016
    19. Long-Term Safety and Efficacy of Dutasteride in the Treatment of Male Patients with Androgenetic Alopecia Journal of Dermatology · 2016
    20. Emotional Consequences of Finasteride: Fool’s Gold American Journal of Men's Health · 2016
    21. 5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder Neuropsychopharmacology · 2015
    22. Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with Low-Dose Finasteride: A Pharmacovigilance Study Pharmacotherapy · 2015
    23. Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride American Journal of Men's Health · 2014
    24. Patients Treated for Male Pattern Hair Loss with Finasteride Show Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma After Discontinuation The Journal of Steroid Biochemistry and Molecular Biology · 2014
    25. Neuroactive Steroid Levels Are Modified in Cerebrospinal Fluid and Plasma of Post-Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology The Journal of Sexual Medicine · 2013
    26. Depressive Symptoms and Suicidal Thoughts Among Former Users of Finasteride With Persistent Sexual Side Effects The Journal of Clinical Psychiatry · 2012
    27. Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010
    28. Finasteride-Induced Depression: New Insights Into Possible Pathomechanisms Journal of Cosmetic Dermatology · 2010
    29. Finasteride Treatment Inhibits Adult Hippocampal Neurogenesis in Male Mice Pharmacopsychiatry · 2010
    30. Finasteride 5mg and Sexual Side Effects: How Many Are Related to a Nocebo Phenomenon? The Journal of Sexual Medicine · 2007
    31. Finasteride Induced Depression: A Prospective Study BMC clinical pharmacology · 2006
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    Related research 6

    1. Evaluation of the Therapeutic Effects of AGA Drugs by Measuring Finasteride, Dutasteride, and Dihydrotestosterone in Hair Clinica Chimica Acta · 2023
    2. What Do We Know About 5-Alpha Reductase Inhibitors? Surgical and Cosmetic Dermatology · 2018
    3. Dutasteride in Androgenetic Alopecia: An Update Current Clinical Pharmacology · 2017
    4. Dutasteride for Men with Androgenic Alopecia Unresponsive to Finasteride Journal of Investigative Dermatology · 2016
    5. Atypical Post-Finasteride Syndrome: A Pharmacological Riddle Indian Journal of Pharmacology · 2016
    6. The Preventive and Therapeutic Efficacy of Finasteride and Dutasteride in TRAMP Mice The FASEB Journal · 2013