Risk of Depression Associated with Finasteride Treatment

    April 2021 in “ Journal of Clinical Psychopharmacology ”
    Maurizio Pompili, C. Magistri, Stefano Maddalena … Ross J. Baldessarini
    Studysummary In this study, finasteride treatment was associated with an increased risk of depression, suicidal ideation, and persistent sexual dysfunction compared to those not treated with the drug.
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    Research cited in this study 21

    1. Physiopathological Role of the Enzymatic Complex 5α-Reductase and 3α/β-Hydroxysteroid Oxidoreductase in the Generation of Progesterone and Testosterone Neuroactive Metabolites Frontiers in Neuroendocrinology · 2020
    2. Post-Finasteride Syndrome: A Surmountable Challenge for Clinicians Fertility and Sterility · 2020
    3. Research Brief: Self-Reports of Persistent Antiandrogenic, Estrogenic, Physical, and Psychological Effects of Finasteride Usage Among Men American Journal of Men's Health · 2018
    4. Neuroactive Steroid Levels and Psychiatric and Andrological Features in Post-Finasteride Patients The Journal of Steroid Biochemistry and Molecular Biology · 2017
    5. Association of Suicidality and Depression With 5α-Reductase Inhibitors JAMA Internal Medicine · 2017
    6. Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss The Journal of Clinical Endocrinology and Metabolism · 2016
    7. Emotional Consequences of Finasteride: Fool’s Gold American Journal of Men's Health · 2016
    8. An Observational Retrospective Evaluation of 79 Young Men with Long-Term Adverse Effects After Use of Finasteride Against Androgenetic Alopecia International Journal of Andrology · 2016
    9. Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with Low-Dose Finasteride: A Pharmacovigilance Study Pharmacotherapy · 2015
    10. Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride American Journal of Men's Health · 2014
    11. Patients Treated for Male Pattern Hair Loss with Finasteride Show Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma After Discontinuation The Journal of Steroid Biochemistry and Molecular Biology · 2014
    12. Neuroactive Steroid Levels Are Modified in Cerebrospinal Fluid and Plasma of Post-Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology The Journal of Sexual Medicine · 2013
    13. Depressive Symptoms and Suicidal Thoughts Among Former Users of Finasteride With Persistent Sexual Side Effects The Journal of Clinical Psychiatry · 2012
    14. Persistent Sexual Side Effects of Finasteride: Could They Be Permanent? The Journal of Sexual Medicine · 2012
    15. Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011
    16. GABAergic Neurosteroids Mediate the Effects of Ethanol on Long-Term Potentiation in Rat Hippocampal Slices European Journal of Neuroscience · 2007
    17. Finasteride Induced Depression: A Prospective Study BMC clinical pharmacology · 2006
    18. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006
    19. Depression Related to Finasteride Administration for Androgenetic Alopecia Journal of Dermatology · 2002
    20. Fortnightly Review: Male Pattern Androgenetic Alopecia BMJ · 1998
    21. Association of Benign Prostatic Hyperplasia with Male Pattern Baldness Urology · 1998

    Related research 3

    1. Similar Efficacy of Maintenance Treatment of Finasteride 1 mg Every Other Month Compared with Finasteride 1 mg Daily in Korean Men with Androgenetic Alopecia After Taking Finasteride 1 mg Daily for 1 Year Journal of The American Academy of Dermatology · 2020
    2. Use of Finasteride in the Treatment of Men With Androgenetic Alopecia Journal of Investigative Dermatology Symposium Proceedings · 2003
    3. Depression Related to Finasteride Administration for Androgenetic Alopecia Journal of Dermatology · 2002