Neuroactive Steroid Levels and Psychiatric and Andrological Features in Post-Finasteride Patients

April 2017 in “ The Journal of Steroid Biochemistry and Molecular Biology ”

Roberto Cosimo Melcangi, Daniele Santi, Roberto Spezzano, M.G. Grimoldi, Tommaso Tabacchi, Maria Fusco, Silvia Diviccaro, Silvia Giatti, Giuseppe Carrà, Donatella Caruso, Manuela Simoni, Guido Cavaletti

finasteride neuroactive steroids post-finasteride syndrome erectile dysfunction major depressive disorder Propecia

Studysummary This study found that patients with post-finasteride syndrome exhibited major depressive disorder, severe erectile dysfunction, and neuropathy, alongside altered neuroactive steroid levels in cerebrospinal fluid.

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The study investigated the levels of neuroactive steroids in post-finasteride syndrome (PFS) patients and their psychiatric and andrological features. The study found that PFS patients had altered levels of neuroactive steroids, which could explain the observed symptoms of erectile dysfunction and major depressive disorder. The study suggests that further research with a larger number of PFS patients and a control group is needed to fully understand the pathogenic mechanism underlying PFS.

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