Exploring the Neural Mechanisms of Finasteride: A Proteomic Analysis in the Nucleus Accumbens

December 2016 in “ Psychoneuroendocrinology ”

Alessio Soggiu, Cristian Piras, Viviana Greco, Paola Devoto, Andrea Urbani, Luigino Calzetta, Marco Bortolato, Paola Roncada

finasteride GABAergic neurotransmission dopaminergic signaling synaptic transmission fatty acid metabolism steroid biosynthetic process Propecia

TLDR Finasteride affects brain processes related to neurotransmission and metabolism, potentially helping with neuropsychiatric conditions.

This study analyzed the effects of finasteride on the proteomic profile of the nucleus accumbens in rats. The results suggest that finasteride may affect key functional processes like GABAergic neurotransmission and dopaminergic signaling, which could account for its therapeutic potential in neuropsychiatric conditions. The study also found that finasteride treatment led to alterations in multiple biological processes, including synaptic transmission and fatty acid metabolism, as well as the regulation of the steroid biosynthetic process.

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11 / 11 results

research Targeting Neurosteroid Synthesis as a Therapy for Schizophrenia-Related Alterations Induced by Early Psychosocial Stress

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A drug improved schizophrenia-like symptoms in stressed rats by changing brain steroid levels.

research Patients Treated for Male Pattern Hair Loss with Finasteride Show Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma After Discontinuation

61 citations , February 2015 in “The Journal of Steroid Biochemistry and Molecular Biology”

Finasteride affects brain and blood steroids, causing lasting sexual and emotional side effects.

research Depressive Symptoms and Suicidal Thoughts Among Former Users of Finasteride With Persistent Sexual Side Effects

134 citations , August 2012 in “The Journal of Clinical Psychiatry”

Former finasteride users with persistent sexual side effects have higher rates of depression and suicidal thoughts.

research Finasteride Attenuates Pathological Gambling in Patients With Parkinson's Disease

35 citations , June 2012 in “Journal of Clinical Psychopharmacology”

Finasteride reduces gambling symptoms in Parkinson's patients.

research Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients

223 citations , March 2011 in “The Journal of Sexual Medicine”

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

research Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders

72 citations , January 2011 in “Current Pharmaceutical Design”

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

research Improvement of General Symptoms in a Chronic Psychotic Patient Treated with Finasteride: Case Report

17 citations , May 2008 in “Pharmacopsychiatry”

Finasteride improved symptoms in a schizophrenia patient.

research Treatment of Tourette’s Syndrome With Finasteride

42 citations , December 2007 in “American Journal of Psychiatry”

Finasteride may effectively reduce Tourette's syndrome symptoms and improve life quality.

research Finasteride Induced Depression: A Prospective Study

99 citations , October 2006 in “BMC clinical pharmacology”

Finasteride may cause slight depression and anxiety.

research Finasteride

125 citations , January 1999 in “Drugs”

Finasteride effectively treats baldness but may cause sexual side effects.

research Finasteride in the Treatment of Men with Androgenetic Alopecia

581 citations , October 1998 in “Journal of The American Academy of Dermatology”

Finasteride safely and effectively treats male pattern hair loss, but may cause reversible sexual issues and harm male fetuses.

2 / 2 results

research Exploring the Neural Mechanisms of Finasteride: A Proteomic Analysis in the Nucleus Accumbens

14 citations , December 2016 in “Psychoneuroendocrinology”

Finasteride affects brain processes related to neurotransmission and metabolism, potentially helping with neuropsychiatric conditions.

research Effect of finasteride, a 5 alpha-reductase inhibitor, on serum gonadotropins in normal men.

30 citations , August 1992 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride doesn't affect hormone levels in normal men.