Exploring the Neural Mechanisms of Finasteride: A Proteomic Analysis in the Nucleus Accumbens

    October 2016 in “ Psychoneuroendocrinology ”
    Alessio Soggiu, Cristian Piras, Viviana Greco, Paola Devoto, Andrea Urbani, Luigino Calzetta, Marco Bortolato, Paola Roncada
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    TLDR Finasteride affects brain processes related to neurotransmission and metabolism, potentially helping with neuropsychiatric conditions.
    This study analyzed the effects of finasteride on the proteomic profile of the nucleus accumbens in rats. The results suggest that finasteride may affect key functional processes like GABAergic neurotransmission and dopaminergic signaling, which could account for its therapeutic potential in neuropsychiatric conditions. The study also found that finasteride treatment led to alterations in multiple biological processes, including synaptic transmission and fatty acid metabolism, as well as the regulation of the steroid biosynthetic process.
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