Exploring the Neural Mechanisms of Finasteride: A Proteomic Analysis in the Nucleus Accumbens

    October 2016 in “ Psychoneuroendocrinology ”
    Alessio Soggiu, Cristian Piras, Viviana Greco, Paola Devoto, Andrea Urbani, Luigino Calzetta, Marco Bortolato, Paola Roncada
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    TLDR Finasteride affects brain processes related to neurotransmission and metabolism, potentially helping with neuropsychiatric conditions.
    This study analyzed the effects of finasteride on the proteomic profile of the nucleus accumbens in rats. The results suggest that finasteride may affect key functional processes like GABAergic neurotransmission and dopaminergic signaling, which could account for its therapeutic potential in neuropsychiatric conditions. The study also found that finasteride treatment led to alterations in multiple biological processes, including synaptic transmission and fatty acid metabolism, as well as the regulation of the steroid biosynthetic process.
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      Can’t tolerate fin, am I screwed?

      community Can’t tolerate fin, am I screwed?

      in Finasteride  113 upvotes 2 days ago
      The user experienced sexual side effects from a topical finasteride and minoxidil combo and stopped using it after three weeks. They plan to use foam minoxidil nightly to slow hair loss and seek alternative treatments that don't affect sexual health.

      community How to safely stop topical finasteride?

      in Finasteride  62 upvotes 3 days ago
      A user is concerned about running out of topical minoxidil and finasteride and seeks advice on safely transitioning to using minoxidil alone. They wish to avoid oral finasteride due to potential side effects and have a dermatologist appointment scheduled.

      community Is it normal that fin tingles in the mouth?

      in Finasteride  59 upvotes 1 week ago
      A user experienced a tingling sensation in their mouth after taking a cut finasteride pill, possibly due to inactive ingredients like mannitol or sodium lauryl sulfate. Tingling is not a common side effect or typical allergy sign, but monitoring for unusual reactions is advised.

      community Switching from finasteride to dutasteride.

      in Finasteride  76 upvotes 1 week ago
      The user has been taking finasteride for nearly 5 years and is now adding dutasteride to their regimen to maintain hair loss prevention. They seek advice on transitioning from finasteride to dutasteride.

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