Targeting Neurosteroid Synthesis as a Therapy for Schizophrenia-Related Alterations Induced by Early Psychosocial Stress

    May 2015 in “ Schizophrenia Research ”
    Roberto Frau, Federico Abbiati, Valentina Bini … Marco Bortolato
    Studysummary This study found that inhibiting the enzyme 5α-reductase with finasteride counteracted stress-induced prepulse inhibition deficits in socially isolated rats by altering neuroactive steroid concentrations in the brain.
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    Research cited in this study 12

    1. Inhibition of 17α-Hydroxylase/C17,20 Lyase Reduces Gating Deficits Consequent to Dopaminergic Activation Psychoneuroendocrinology · 2013
    2. Inhibition Of 5α-Reductase Attenuates Behavioral Effects Of D1-, But Not D2-Like Receptor Agonists In C57BL/6 Mice Psychoneuroendocrinology · 2012
    3. Finasteride Attenuates Pathological Gambling in Patients With Parkinson's Disease Journal of Clinical Psychopharmacology · 2012
    4. Inhibition of 5α-Reductase in the Nucleus Accumbens Counters Sensorimotor Gating Deficits Induced by Dopaminergic Activation Psychoneuroendocrinology · 2011
    5. A Preliminary Study of Finasteride in Tourette Syndrome Movement Disorders · 2011
    6. Isolation Rearing-Induced Reduction of Brain 5α-Reductase Expression: Relevance to Dopaminergic Impairments Neuropharmacology · 2011
    7. Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders Current Pharmaceutical Design · 2011
    8. Inhibition of Human Steroid 5β-Reductase (AKR1D1) by Finasteride and Structure of the Enzyme-Inhibitor Complex Journal of Biological Chemistry · 2009
    9. Improvement of General Symptoms in a Chronic Psychotic Patient Treated with Finasteride: Case Report Pharmacopsychiatry · 2008
    10. Antipsychotic-Like Properties of 5-Alpha-Reductase Inhibitors Neuropsychopharmacology · 2008
    11. Treatment of Tourette’s Syndrome With Finasteride American Journal of Psychiatry · 2007
    12. Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP-Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor Journal of the American Chemical Society · 1996