The Influence of Low Dose Finasteride, a Type II 5α-Reductase Inhibitor, on Circulating Neuroactive Steroids

    September 2009 in “ Hormone Molecular Biology and Clinical Investigation ”
    Michaela Duskova, Martin Hill, Luboslav Stárka
    Studysummary This study found that low-dose finasteride treatment in men with premature androgenetic alopecia decreased levels of 5α-reduced steroids, which may be linked to increased depression symptoms.
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    Research cited in this study 15

    1. Finasteride-Induced Myalgia and HyperCKemia Journal of Clinical Neuromuscular Disease · 2008
    2. Intraoperative Floppy-Iris Syndrome and Finasteride Intake Journal of Cataract and Refractive Surgery · 2007
    3. GABAergic Neurosteroids Mediate the Effects of Ethanol on Long-Term Potentiation in Rat Hippocampal Slices European Journal of Neuroscience · 2007
    4. Finasteride 5mg and Sexual Side Effects: How Many Are Related to a Nocebo Phenomenon? The Journal of Sexual Medicine · 2007
    5. Inhibition of Progesterone Metabolism Mimics the Effect of Progesterone Withdrawal on Forced Swim Test Immobility Pharmacology Biochemistry and Behavior · 2007
    6. Spermatozoa and Chronic Treatment with Finasteride: A TEM and FISH Study Archives of Andrology · 2007
    7. The Anxiolytic Effect of Pregnancy in Rats Is Reversed by Finasteride Pharmacology, Biochemistry and Behavior · 2006
    8. Finasteride Induced Depression: A Prospective Study BMC clinical pharmacology · 2006
    9. Lack of Evidence of a Role for the Neurosteroid Allopregnanolone in Ethanol-Induced Reward and c-Fos Expression in DBA/2 Mice Brain Research · 2006
    10. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006
    11. Hepatitis por finasterida Farmacia Hospitalaria · 2006
    12. Depression Related to Finasteride Administration for Androgenetic Alopecia Journal of Dermatology · 2002
    13. Finasteride, a Type 2 5α-Reductase Inhibitor, in the Treatment of Men with Androgenetic Alopecia Expert Opinion on Investigational Drugs · 1999
    14. Clinical and Endocrine Effects of Finasteride, a 5α-Reductase Inhibitor, in Women with Idiopathic Hirsutism Fertility and Sterility · 1995
    15. Altered Brain And Pituitary Androgen Metabolism By Prenatal, Perinatal Or Pre- And Postnatal Finasteride, Flutamide Or Dihydrotestosterone Treatment In Juvenile Male Rats Progress in Neuro-psychopharmacology & Biological Psychiatry · 1993

    Related research 15

    1. Evaluation of Sex Hormone Levels in Benign Prostatic Hyperplasia Patients Treated with 5 Alpha-Reductase Inhibitor (Finasteride) in Amara City, Iraq Baghdad Science Journal · 2020
    2. A Review on Finasteride: A 5-Alpha Reductase Inhibitor, Its Mechanism, Facts, and Benefits Journal of Drug Delivery and Therapeutics · 2019
    3. Long-Term Treatment with Finasteride Induces Apoptosis and Pathological Changes in Female Mice Human & Experimental Toxicology · 2019
    4. Finasteride as a Treatment for Male Androgenetic Alopecia e-Jurnal Medika Udayana · 2013
    5. Pharmacokinetics of Two Novel Formulations of Modified-Release Oral Testosterone Alone and With Finasteride in Normal Men With Experimental Hypogonadism International Journal of Andrology · 2010
    6. Finasteride Treatment and Neuroactive Steroid Formation PubMed · 2009
    7. Effect of Selective 5alpha-Reductase Inhibitor and/or Testosterone Undecanoate on the Reproductive Function of Male Rats PubMed · 2005
    8. 5α-Reductase Inhibitors in the Treatment of Androgenetic Alopecia International Journal of Cosmetic Surgery and Aesthetic Dermatology · 2001
    9. A Prospective Randomized Trial Comparing Low Dose Flutamide, Finasteride, Ketoconazole, and Cyproterone Acetate-Estrogen Regimens in the Treatment of Hirsutism The Journal of Clinical Endocrinology and Metabolism · 1999
    10. Finasteride: A New Drug for the Treatment of Male Hirsutism and Androgenetic Alopecia? PubMed · 1996
    11. Clinical Pharmacokinetics and Pharmacodynamics of Finasteride Clinical Pharmacokinectics · 1996
    12. Comparison of Finasteride (Proscar) and Serenoa Repens (Permixon) in the Inhibition of 5-Alpha Reductase in Healthy Male Volunteers European Urology · 1994
    13. Finasteride: The First 5 Alpha-Reductase Inhibitor PubMed · 1993
    14. Hair Growth Effects of Oral Administration of Finasteride, a Steroid 5 Alpha-Reductase Inhibitor, Alone and in Combination with Topical Minoxidil in the Balding Stumptail Macaque The Journal of Clinical Endocrinology and Metabolism · 1992
    15. Effects of Finasteride (MK-906), a 5α-Reductase Inhibitor, on Circulating Androgens in Male Volunteers The Journal of Clinical Endocrinology and Metabolism · 1990