Effect of Selective 5alpha-Reductase Inhibitor and/or Testosterone Undecanoate on the Reproductive Function of Male Rats

    January 2005 in “ PubMed
    Yue Jia, Yu-gui Cue, Xiaodong Wang, Xinghai Wang, Jian-Sun Tong, Ding-zhi Ma, Ruifen Cai, Fu-Song Di
    TLDR Testosterone undecanoate can reduce the negative effects of Finasteride on male reproductive health.
    The study investigated the effects of high dosages of the 5alpha-reductase inhibitor, Finasteride, on male reproductive function in rats. It was found that Finasteride alone could suppress reproductive function. However, when Finasteride was administered in combination with testosterone undecanoate (TU), the inhibiting effects on reproductive function were counteracted. This suggested that TU could mitigate the negative impact of Finasteride on male reproductive health.
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