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Glossary Testosterone Undecanoate

long-acting testosterone ester used in hormone replacement therapy

Testosterone Undecanoate (TU) is a long-acting ester of testosterone used primarily in hormone replacement therapy for men with low testosterone levels. It is administered either orally or via intramuscular injection and helps maintain stable testosterone levels in the body, which can improve symptoms such as fatigue, low libido, and muscle weakness.

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Research

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research Effects of Intramuscular Testosterone Undecanoate on Body Composition and Bone Mineral Density in Female-to-Male Transsexuals

105 citations , June 2010 in “The journal of sexual medicine”

In this study, female-to-male transsexuals treated with long-acting testosterone undecanoate experienced an increase in lean mass but no change in fat mass or bone mineral density over 24 months.

research A Randomized Double-Blind Placebo-Controlled Pilot Trial on the Effects of Testosterone Undecanoate Plus Dutasteride or Placebo on Muscle Strength, Body Composition, and Metabolic Profile in Transmen

7 citations , January 2021 in “The Journal of Sexual Medicine”

This study demonstrated that testosterone treatment increases muscle strength and alters body composition in transmen, and the addition of dutasteride does not impair these anabolic effects.

research Exploring the efficacy of testosterone undecanoate in male children with 5α‐reductase deficiency

5 citations , December 2021 in “Pediatric investigation”

In this study, children with 5-alpha-reductase deficiency and micropenis treated with oral testosterone undecanoate showed increased penile length to a target level after 3-9 months, with no severe adverse effects observed, suggesting the treatment's safety and efficacy.

research EFFECT OF A COMBINATION OF DUTASTERIDE AND PARENTERAL TESTOSTERONE UNDECANOATE ON TESTOSTERONE DEFICIENCY SYMPTOMS AND PROSTATE IN PATIENTS WITH TESTOSTERONE DEFICIENCY AND BENIGN PROSTATIC HYPERPLASIA

January 2020 in “Journal of Men s Health”

In this study of BPH patients with testosterone deficiency, the combination of TU and dutasteride reduced prostate volume and improved testosterone-related symptoms but was less effective for sexual function compared to TU alone, indicating caution in using dutasteride for those with sexual dysfunction concerns.

research [Effect of selective 5alpha-reductase inhibitor or/and testosterone undecanoate on the reproductive function of male rats].

January 2005 in “PubMed”

This study suggests that the negative impact of high-dose Finasteride on male reproductive function may be mitigated by concurrent administration with TU.

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Community Join

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community 5mg cialis daily to deal with dutasteride

in Finasteride/Dutasteride 71 upvotes 9 months ago

Cialis is used to manage erectile dysfunction caused by finasteride and dutasteride, with mixed results. Some users report improvement, while others consider stopping the medication due to side effects.

community Next month marks 2 years on Dutasteride. When does it start working?

in Finasteride/Dutasteride 36 upvotes 2 years ago

A user has been on dutasteride for nearly 2 years with no improvement in hair loss, expressing frustration. Other users suggest checking for other health conditions, getting bloodwork, and considering stopping TRT or trying finasteride.

community Testosterone increased after six months of finasteride

12 upvotes 3 months ago

A 23-year-old male experienced an increase in testosterone levels after taking 1 mg of finasteride daily for six months, with no significant side effects reported. Users discussed how finasteride inhibits DHT, leading to increased testosterone, and debated the psychological versus physiological effects of the medication.

community Can testosterone alone cause hair loss even after nuking DHT?

in Research/Science 26 upvotes 8 months ago

Testosterone can still cause hair loss even when DHT is blocked by dutasteride, especially if hair follicles are sensitive. Topical treatments like RU58841 or pyrilutamide may help, but their long-term effectiveness is uncertain compared to dutasteride.

community Testosterone and Estradiol levels on 1 mg/day dutasteride

43 upvotes 11 months ago

A 30-year-old man experienced significant hair regrowth and improved libido after using finasteride and dutasteride for androgenetic alopecia, with no adverse effects. He plans to reduce dutasteride dosage when trying to conceive and has been using topical minoxidil since 2015.

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Learn

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learn Bicalutamide

Could bicalutamide help trans women regrow hair lost to testosterone? No study has tested bicalutamide for hair regrowth in trans women. In cisgender women the only randomized trial found it added nothing to minoxidil, and it is an off-label prescription drug that requires liver monitoring.

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