Finasteride: A New Drug for the Treatment of Male Hirsutism and Androgenetic Alopecia?

June 1996 in “ PubMed ”

G. Spinucci, Renato Pasquali

finasteride androgenetic alopecia dihydrotestosterone DHT type II 5 alpha-reductase hirsutism hyperandrogenism anagen phase Propecia

TLDR Finasteride may help reduce male hair loss and excessive hair growth by lowering DHT levels.

Finasteride was studied for its potential in treating male hirsutism and androgenetic alopecia by inhibiting the conversion of testosterone to dihydrotestosterone (DHT), particularly affecting type II 5 alpha-reductase. The drug showed promise in reducing hirsutism in women with hyperandrogenism and improving hair follicle characteristics in men with alopecia by increasing the number of follicles in the anagen phase and decreasing DHT levels in the scalp. This review summarized findings from recent studies and discussed the future potential of finasteride in these contexts.

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community The Real Cause Of Androgenetic Alopecia

in Research/Science 675 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 2 years ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 96 upvotes 5 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community risks with finasteride and dutasteride

in Research/Science 140 upvotes 4 months ago

Finasteride and dutasteride have potential risks, including post-finasteride syndrome, but are commonly used for hair loss. RU58841, minoxidil, and needling are suggested as alternatives, though all treatments carry risks.

community Why I really believe the tension theory is the cause of MPB

in Research/Science 70 upvotes 4 years ago

The conversation discusses the tension theory as a cause of male pattern baldness (MPB), suggesting that scalp tension and reduced subcutaneous fat layer contribute to hair loss. Treatments mentioned include Minoxidil, finasteride, microneedling, scalp massages, and Botox.

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research Proscar and Propecia: The Gary and Jerry Show

September 2020 in “Oxford University Press eBooks”

Unable to provide a summary as the provided text does not contain enough information.

research The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness

59 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride reduces scalp DHT levels, potentially treating male pattern baldness.

research Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men

30 citations , August 1992 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride doesn't affect hormone levels in normal men.