Pharmacokinetics of Two Novel Formulations of Modified-Release Oral Testosterone Alone and With Finasteride in Normal Men With Experimental Hypogonadism

November 2010 in “ International Journal of Andrology ”

C. N. Snyder, Richard F. Clark, Ralph B. Caricofe, Mark B. Bush, Mara Y. Roth, Stephanie T. Page, William J. Bremner, John K. Amory

TLDR New oral testosterone formulations show potential for safer, effective hormone replacement in men with low testosterone.

This study investigated the pharmacokinetics of two novel formulations of modified-release oral testosterone, alone and with finasteride, in normal men with experimental hypogonadism. The modified slow-release formulation appears to prevent the transient postdose supraphysiologic peaks in serum hormone levels observed with the other formulations by slowing hormone absorption. This formulation appears to be attractive for further development as an oral form of testosterone and will be the focus of future studies investigating the safety and efficacy of this approach to androgen replacement therapy in hypogonadal men.

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3 / 3 results

research Nanomilled Oral Testosterone Plus Dutasteride Effectively Normalizes Serum Testosterone in Normal Men With Induced Hypogonadism

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195 citations , May 2007 in “The Journal of Clinical Endocrinology and Metabolism”

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2 / 2 results

research Comparison of Finasteride (Proscar) and Serenoa Repens (Permixon) in the Inhibition of 5-Alpha Reductase in Healthy Male Volunteers

73 citations , January 1994 in “European Urology”

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research Effects of Finasteride (MK-906), a 5α-Reductase Inhibitor, on Circulating Androgens in Male Volunteers

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Finasteride safely lowers DHT levels without affecting testosterone.