Pharmacokinetics of Two Novel Formulations of Modified-Release Oral Testosterone Alone and With Finasteride in Normal Men With Experimental Hypogonadism

November 2010 in “ International Journal of Andrology ”

C. N. Snyder, Richard F. Clark, Ralph B. Caricofe, Mark B. Bush, Mara Y. Roth, Stephanie T. Page, William J. Bremner, John K. Amory

testosterone modified-release oral testosterone finasteride hypogonadism androgen replacement therapy Propecia

TLDR New oral testosterone formulations show potential for safer, effective hormone replacement in men with low testosterone.

This study investigated the pharmacokinetics of two novel formulations of modified-release oral testosterone, alone and with finasteride, in normal men with experimental hypogonadism. The modified slow-release formulation appears to prevent the transient postdose supraphysiologic peaks in serum hormone levels observed with the other formulations by slowing hormone absorption. This formulation appears to be attractive for further development as an oral form of testosterone and will be the focus of future studies investigating the safety and efficacy of this approach to androgen replacement therapy in hypogonadal men.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

Nanomilled Oral Testosterone Plus Dutasteride Effectively Normalizes Serum Testosterone in Normal Men With Induced Hypogonadism

research Nanomilled Oral Testosterone Plus Dutasteride Effectively Normalizes Serum Testosterone in Normal Men With Induced Hypogonadism

10 citations, February 2008 in “International Journal of Andrology”

A combination of nanomilled oral testosterone and dutasteride normalized testosterone levels in men with low testosterone and is safe for short-term use.

research The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men

195 citations, February 2007 in “The Journal of Clinical Endocrinology and Metabolism”

Dutasteride and finasteride may reduce sperm count and volume but don't affect movement or shape; effects are reversible after stopping.

research Oral Testosterone in Oil: Pharmacokinetic Effects of 5α-Reduction by Finasteride or Dutasteride and Food Intake in Men

22 citations, January 2006 in “International Journal of Andrology”

Taking oral testosterone with finasteride or dutasteride doubles testosterone levels, and food slightly affects it.

Related Community Posts Join

6 / 1000+ results

community Serious question, is there nothing that can be done if Dutasteride doesn’t help to stop my hair loss?

in Finasteride/Dutasteride 61 upvotes 2 years ago

A 25 year old male who has been using finasteride and dutasteride for two years to treat his hair loss, with no success. Other treatments such as oral minoxidil, topical anti-androgens, RU58841, latanoprost, topical estrogen, CB 03 01, microneedling, keto 2% shampoo, vitamin D, Omega 3, B vitamins and probiotics were discussed.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community hmi115 is coming. Prepare yourselves for what's coming

in Technology 106 upvotes 1 year ago

The conversation discusses HMI-115, a potential cure for hair loss. Users share mixed opinions, with some expressing skepticism and others sharing anecdotal evidence of its effectiveness, including photos of significant hair regrowth from a trial participant.

community 15 years of finasteride/minoxidil

in Update 194 upvotes 6 months ago

A user shared a 15-year experience using minoxidil and finasteride for hair loss, stating that despite never missing a dose, their hairline continued to recede slowly. Other users suggested that the hair loss might be exacerbated by the use of steroids and recommended considering other treatments like dutasteride and RU58841.

community Does lowering serum prolactin lower prolactin in the scalp?

in Research/Science 13 upvotes 9 months ago

The conversation discusses whether not masturbating (semen retention) affects hair loss, with opinions varying but generally dismissing the idea. Some participants mention using hair loss treatments like Minoxidil, Finasteride, and RU58841, but the effectiveness and relation to prolactin levels in the scalp are debated.

community Finasteride only reduces scalp DHT by ~40%. Why does it work?

in Finasteride/Dutasteride 37 upvotes 1 year ago

How Finasteride and Dutasteride help reduce hair loss by reducing the amount of DHT in scalp areas, as well as discussing factors such as sensitivity to DHT, 5α-reductase expression in different parts of the hair follicle, and scalp tension.

Related Research

2 / 2 results

research Comparison of Finasteride (Proscar) and Serenoa Repens (Permixon) in the Inhibition of 5-Alpha Reductase in Healthy Male Volunteers

73 citations, January 1994 in “European Urology”

Finasteride works better than Permixon in reducing dihydrotestosterone levels.

research Effects of Finasteride (MK-906), a 5α-Reductase Inhibitor, on Circulating Androgens in Male Volunteers

147 citations, April 1990 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride safely lowers DHT levels without affecting testosterone.