Comparison of Finasteride (Proscar) and Serenoa Repens (Permixon) in the Inhibition of 5-Alpha Reductase in Healthy Male Volunteers

January 1994 in “ European Urology ”

Georges Strauch, P Perles, Gerard Vergult, Munir Gabriel, B Gibelin, Stuart Cummings, William Malbecq, Marie-Pierre Malice

finasteride Serenoa repens Permixon 5-alpha reductase dihydrotestosterone benign prostatic hyperplasia Proscar Permixon DHT BPH

TLDR Finasteride works better than Permixon in reducing dihydrotestosterone levels.

This study compared the effectiveness of finasteride and Permixon in inhibiting 5-alpha reductase in healthy male volunteers. Finasteride was found to be more effective than Permixon in reducing serum dihydrotestosterone levels, confirming its potent and specific inhibition of 5-alpha reductase. The study suggests that finasteride may be a more effective treatment for conditions related to 5-alpha reductase, such as benign prostatic hyperplasia.

View this study on karger.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

in Research/Science 104 upvotes 2 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

community Serenoa Repens (saw palmetto) + plus biotin

in Chat 5 upvotes 1 year ago

A user is using minoxidil for hair loss and considering adding finasteride but their dermatologist advised waiting to see if minoxidil works alone. They are thinking about taking saw palmetto (serenoa repens) and biotin as alternatives and are asking for others' experiences and potential side effects.

community THE BEST SERENOA REPENS (saw palmetto) SUPPLEMENT

in Product 1 year ago

The conversation is about finding the best quality and price for a saw palmetto supplement for hair loss. Specific treatments mentioned are Minoxidil, Finasteride, and RU58841.

community Which Saw Palmetto is good for blocking 5 alpha reductase, Serenoa repens or Chamaerops humilis?

in Finasteride/Dutasteride 4 years ago

The conversation is about determining which type of Saw Palmetto, either Chamaerops humilis or Serenoa repens, is effective for inhibiting the 5 alpha reductase enzyme related to hair loss. Specific treatments mentioned are Minoxidil, finasteride, and RU58841.

community Treatment of male androgenetic alopecia with topical products containing Serenoa repens (Saw Palmetto) extract.

3 upvotes 9 years ago

The conversation discusses treating male pattern baldness with topical products containing Saw Palmetto extract. Specific treatments mentioned include Minoxidil, Finasteride, and RU58841.

community I’m Feeling so discouraged and depressed - No one wants to prescribe finasteride to me.

in Finasteride/Dutasteride 68 upvotes 11 months ago

A user in France is frustrated because three dermatologists refused to prescribe finasteride for their hair loss, suggesting it's not androgenetic alopecia (AGA) and offering expensive vitamin treatments instead. Other users suggest buying hair loss treatments like minoxidil and finasteride from various online pharmacies and considering a gender-affirming care physician for more understanding treatment options.

Related Research

2 / 2 results

research A Risk-Benefit Assessment of Treatment with Finasteride in Benign Prostatic Hyperplasia

12 citations, January 1998 in “Drug safety”

Finasteride helps reduce prostate size and symptoms in BPH but is less effective than terazosin and works best for larger prostates.

research Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men

30 citations, August 1992 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride doesn't affect hormone levels in normal men.