Inhibition of Progesterone Metabolism Mimics the Effect of Progesterone Withdrawal on Forced Swim Test Immobility

    June 2007 in “ Pharmacology Biochemistry and Behavior ”
    Ethan H. Beckley, Deborah A. Finn
    Studysummary In this study, withdrawal from progesterone and treatment with finasteride were associated with increased signs of depression-like behavior in female mice, suggesting decreased allopregnanolone levels may play a role.
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    Research cited in this study 6

    1. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006
    2. Attenuating 5α-Pregnane-3α-Ol-20-One Formation in the Hippocampus of Female Rats Increases Pentylenetetrazole-Induced Seizures Epilepsy & Behavior · 2005
    3. Interaction of Chronic Ethanol Exposure and Finasteride: Sex and Strain Differences Pharmacology, Biochemistry and Behavior · 2004
    4. The Role of Pregnane Neurosteroids in Ethanol Withdrawal: Behavioral Genetic Approaches Pharmacology & Therapeutics · 2004
    5. Progesterone Enhances Ethanol-Induced Modulation of Mesocortical Dopamine Neurons: Antagonism by Finasteride Journal of Neurochemistry · 2002
    6. Changes in Progesterone Metabolites in the Hippocampus Can Modulate Open Field and Forced Swim Test Behavior of Proestrous Rats Hormones and Behavior · 2002

    Related research 1

    1. Finasteride Inhibits the Progesterone-Induced Spike-Wave Discharges in a Genetic Model of Absence Epilepsy Pharmacology, Biochemistry and Behavior · 2003