Attenuating 5α-Pregnane-3α-Ol-20-One Formation in the Hippocampus of Female Rats Increases Pentylenetetrazole-Induced Seizures

    February 2005 in “ Epilepsy & Behavior ”
    Madeline E. Rhodes, Cheryl A. Frye
    Studysummary The researchers reported that metabolism of progesterone to 3α,5α-THP in the hippocampus is important for its antiseizure effects in ovariectomized rats.
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    Research cited in this study 3

    1. Finasteride Blocks the Reduction in Ictal Activity Produced by Exogenous Estrous Cyclicity Journal of Neuroendocrinology · 2008
    2. Anticonvulsant Activity of Progesterone and Neurosteroids in Progesterone Receptor Knockout Mice Journal of Pharmacology and Experimental Therapeutics · 2004
    3. Progesterone, Neurosteroids, and the Hormonal Basis of Catamenial Epilepsy Annals of Neurology · 2003

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