In this study, treatment with a 5a-reductaseinhibitor increased CD8+ T cell infiltration in benign prostatic hyperplasia tissues, suggesting an impact on inflammatory responses.
12 citations
,
April 1995 in “Journal of Medicinal Chemistry”
In this study, 4-substituted N-(1,1-dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides were synthesized and evaluated in vitro as potential 5 alpha-reductaseinhibitors and antiandrogens.
21 citations
,
August 1994 in “Clinical endocrinology”
This article reviews the effects of 5 alpha-reductaseinhibitors for treating conditions like male pattern baldness and benign prostatic hyperplasia, noting significant DHT reduction but reports no new clinical results.
92 citations
,
October 2002 in “Journal of The American Academy of Dermatology”
This study reports that oral finasteride improved or stabilized hair loss in women with hyperandrogenism but not in postmenopausal women with female pattern hair loss.
Finasteride may affect neurosteroids, impacting mood and sexual function, with varied user experiences. Some report side effects like depression and sexual dysfunction, while others find it effective for hair retention or prefer alternatives like Dutasteride or topical treatments.
Finasteride may pose a risk during pregnancy, so using a condom is recommended if a partner is pregnant. It is advised to stop finasteride before trying to conceive due to potential effects on fetal development.
The user is experiencing significant hair loss after switching from finasteride to dutasteride for five months. Suggestions include that the hair loss might be a normal shedding phase, with some recommending continuing the treatment for up to 24 months or considering alternatives like RU58841.
Hair regrowth typically levels out after several months of treatment with finasteride, dutasteride, and minoxidil, with many users experiencing stabilization rather than significant regrowth. Starting treatment early is crucial, as regrowth is rare beyond Norwood 3 without additional interventions like hair transplants.