Finasteride, a 5α-Reductase Inhibitor, Potentiates Antinociceptive Effects of Morphine, Prevents the Development of Morphine Tolerance and Attenuates Abstinence Behavior in the Rat

May 2007 in “ Hormones and Behavior ”

Javad Verdi, Abolhassan Ahmadiani

TLDR Finasteride boosts morphine's pain relief, stops tolerance, and reduces withdrawal in rats.

The study found that finasteride, a 5α-reductase inhibitor, enhanced the pain-relieving effects of morphine, prevented the development of tolerance to morphine, and reduced withdrawal symptoms in rats. This suggests its potential use in pain management and as a treatment for opioid addiction.

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research Finasteride, a 5α-Reductase Inhibitor, Potentiates Antinociceptive Effects of Morphine, Prevents the Development of Morphine Tolerance and Attenuates Abstinence Behavior in the Rat

15 citations , May 2007 in “Hormones and Behavior”

Finasteride boosts morphine's pain relief, stops tolerance, and reduces withdrawal in rats.