Adverse Event Reporting in Clinical Trials of Finasteride for Androgenic Alopecia: A Meta-Analysis

    April 2015 in “ PubMed
    Steven M. Belknap, Imran Aslam, Tina Kiguradze, William H. Temps, Paul R. Yarnold, John Cashy, Robert E. Brannigan, Giuseppe Micali, Beatrice Nardone, Dennis P. West
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    TLDR Finasteride for hair loss may cause long-lasting side effects like impotence and low libido, but trials lack proper safety reporting.
    This meta-analysis evaluated the safety reporting of clinical trials of finasteride for androgenic alopecia (AGA) and found that none of the 34 clinical trials analyzed had adequate safety reporting. The quality of adverse event reporting in clinical trials of finasteride for AGA was inadequate, and recent reports describe that impotence, loss of libido, low androgen levels, and severe oligospermia may persist long after discontinuation of finasteride at a dosage of 1.25 mg/d or less. The study concludes that validated, effective methods for detecting adverse events, grading their severity, and evaluating causality should be used in clinical trials to identify and characterize drug toxicity.
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      in Research/Science  22 upvotes 8 months ago
      The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.

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      in Chat  247 upvotes 2 years ago
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      community DHT and 5AR respect post, it's importance within the brain

      in Research/Science  111 upvotes 8 months ago
      The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

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