Association of Suicidality and Depression With 5α-Reductase Inhibitors

    March 2017 in “ JAMA Internal Medicine ”
    Blayne Welk, Eric McArthur, Michael Ordon … Stephanie N. Dixon
    Studysummary In this study, older men using 5α-reductase inhibitors for prostatic enlargement did not show increased risk of suicide, but had elevated risks of self-harm and depression.
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    Research cited in this study 10

    1. Emotional Consequences of Finasteride: Fool’s Gold American Journal of Men's Health · 2016
    2. Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with Low-Dose Finasteride: A Pharmacovigilance Study Pharmacotherapy · 2015
    3. On the Effects of Testosterone on Brain Behavioral Functions Frontiers in Neuroscience · 2015
    4. Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride American Journal of Men's Health · 2014
    5. Neuroactive Steroid Levels Are Modified in Cerebrospinal Fluid and Plasma of Post-Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology The Journal of Sexual Medicine · 2013
    6. Central 5-Alpha Reduction of Testosterone Is Required for Testosterone's Inhibition of the Hypothalamo-Pituitary-Adrenal Axis Response to Restraint Stress in Adult Male Rats Brain Research · 2013
    7. Depressive Symptoms and Suicidal Thoughts Among Former Users of Finasteride With Persistent Sexual Side Effects The Journal of Clinical Psychiatry · 2012
    8. 5α-Reductases in Human Physiology: An Unfolding Story Endocrine Practice · 2012
    9. The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia The New England Journal of Medicine · 2003
    10. Depression Related to Finasteride Administration for Androgenetic Alopecia Journal of Dermatology · 2002