Search

for
Search:

Glossary5α-reductase inhibitors (5ARIs)

block enzyme converting testosterone to hair-loss-causing DHT

5α-reductase inhibitors, also known as 5-ARIs, are medications that block the enzyme 5α-reductase. This enzyme converts testosterone into dihydrotestosterone (DHT), a hormone that can contribute to conditions like male pattern baldness and benign prostatic hyperplasia (BPH). By inhibiting this enzyme, 5-ARIs can help reduce hair loss and shrink an enlarged prostate.

Related Terms

Learn

0 / 0 results

— no results

Research

5 / 327 results

No Increased Risk of Breast or Gynecologic Cancers in Women with 5α-Reductase Inhibitor Exposure for Female Pattern Hair Loss: A Population-Based Propensity Score-Matched Cohort Study

research No Increased Risk of Breast or Gynecologic Cancers in Women with 5α-Reductase Inhibitor Exposure for Female Pattern Hair Loss: A Population-Based Propensity Score-Matched Cohort Study

September 2025 in “Journal of the American Academy of Dermatology”

Using 5α-reductase inhibitors for hair loss in women doesn't increase cancer risk.

research 5-Alpha-Reductase Inhibitors for Lower Urinary Tract Symptoms Secondary to Benign Prostatic Obstruction

1 citations , November 2015 in “Cochrane library”

5-alpha-reductase inhibitors help treat urinary symptoms from an enlarged prostate.

research Editor's Picks January 2021

January 2021 in “Journal of the European Academy of Dermatology and Venereology”

PrEP doesn't increase STI risk in high-risk men, anti-androgen drugs may lower ICU admission for male COVID-19 patients, a 3-point injection is better for crow's feet, and the 'Geriatric-8' tool could help assess frailty in older skin cancer patients.

research Five-Alpha Reductase Inhibitor and Breast Cancer Risk in Men: A Systematic Review

2 citations , January 2017 in “Annals of Dermatology”

Taking 5-alpha reductase inhibitors does not increase breast cancer risk in men.

research Evaluating 5 Alpha Reductase Inhibitors for the Treatment of Male Androgenic Alopecia

November 2023 in “Expert Opinion on Pharmacotherapy”

Finasteride and dutasteride are effective in treating male hair loss but can cause sexual side effects and birth defects.

View more "5aris" in research →

Community Join

5 / 358 results

community Do People even realize that we got a new Treatment Option and Kintor Officially released Pyrilutamide?

in Treatment 56 upvotes 1 year ago

A new hair loss treatment, Pyrilutamide, has been released and is claimed to be a strong anti-androgen, potentially effective when used with finasteride. However, there are mixed opinions on its effectiveness and safety, with some users skeptical and others purchasing it.

community Dutasteride 1 year regression. Depressing. (With pictures for proof)

in Progress Pictures 14 upvotes 2 years ago

A user shared their experience of hair loss progression after one year on dutasteride, expressing disappointment with no improvement and considering other treatments like RU58841. Other users offered mixed responses, some seeing no change, others suggesting the hair loss might have been worse without treatment, and discussing the role of testosterone and DHT in hair loss.

community 20M NW6 diffuse —> NW1 Fin/Dut

in Progress Pictures 72 upvotes 1 year ago

A user shared progress pictures showing improvement from NW6 diffuse to NW1 after 5 months of finasteride and 2 months of dutasteride. Another user asked if these treatments affected beard or body hair thickness.

community Why anecdotal evidence is so valued around here?

in Chat 18 upvotes 1 year ago

The conversation discusses why personal stories about hair loss treatments like Minoxidil and finasteride are often taken more seriously than scientific evidence in certain forums. People tend to believe what they want and use others' experiences to support their own views on treatment effectiveness and side effects.

community 50% test increase after 18 months of taking DUT

in Update 57 upvotes 1 year ago

A user reported a 50% increase in testosterone after 18 months of taking dutasteride for hair loss. The conversation includes skepticism about the reliability of single testosterone tests and questions about estrogen levels.

View more "5aris" in community →