TLDR Taking 5 alpha reductase inhibitor medication slightly increases the risk of depression, especially as you get older.
In 2020, a meta-analysis involving 425,357 participants was conducted to examine the link between 5 alpha reductase inhibitor (5ARI) medication, used for hair loss and prostate enlargement, and depression. The results showed that users of 5ARI medications had a higher risk of developing depression. However, the overall hazard ratio (HR) for depression after 5-ARI medication was 1.23 and the overall odds ratio (OR) was 1.19, which were not statistically significant. The risk of depression was found to increase with age. The study concluded that while the risk of depression was not significantly high, the results should be interpreted with caution due to the limited number of studies included.
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August 2012 in “The Journal of Clinical Psychiatry” Former finasteride users with persistent sexual side effects have higher rates of depression and suicidal thoughts.
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July 2012 in “The Journal of Sexual Medicine” Finasteride may cause long-lasting sexual side effects.
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June 2012 in “PubMed” There are potential treatments for pattern baldness, but more research is needed to confirm their effectiveness.
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December 2003 in “The New England Journal of Medicine” Combination therapy of doxazosin and finasteride safely and effectively reduces benign prostatic hyperplasia progression risk.
