Risk of Depression After 5 Alpha Reductase Inhibitor Medication: Meta-Analysis

    May 2019 in “ The World Journal of Men's Health ”
    Jae Heon Kim, Sung Ryul Shim, Yash S. Khandwala … Benjamin I. Chung
    Studysummary This study found no significant increase in depression risk associated with taking five-alpha reductase inhibitors for benign prostatic hyperplasia or alopecia, although further studies are needed to confirm these findings.
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    Research cited in this study 8

    1. Association of Suicidality and Depression With 5α-Reductase Inhibitors JAMA Internal Medicine · 2017
    2. Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride American Journal of Men's Health · 2014
    3. Central 5-Alpha Reduction of Testosterone Is Required for Testosterone's Inhibition of the Hypothalamo-Pituitary-Adrenal Axis Response to Restraint Stress in Adult Male Rats Brain Research · 2013
    4. Depressive Symptoms and Suicidal Thoughts Among Former Users of Finasteride With Persistent Sexual Side Effects The Journal of Clinical Psychiatry · 2012
    5. Persistent Sexual Side Effects of Finasteride: Could They Be Permanent? The Journal of Sexual Medicine · 2012
    6. 5α-Reductases in Human Physiology: An Unfolding Story Endocrine Practice · 2012
    7. Promising Therapies for Treating and Preventing Androgenic Alopecia PubMed · 2012
    8. The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia The New England Journal of Medicine · 2003