Medical Management of Benign Prostatic Hyperplasia

March 2024 in “ Cleveland Clinic journal of medicine ”

Eiftu Haile, Ayodeji E. Sotimehin, Bradley C. Gill

5-alpha reductase inhibitors alpha-blockers phosphodiesterase-5 inhibitors beta-3 agonists 5-ARI PDE5 inhibitors

TLDR Alpha-blockers and 5-alpha reductase inhibitors are main treatments for BPH, with new support for phosphodiesterase-5 inhibitors and beta-3 agonists.

Medical management of benign prostatic hyperplasia (BPH) has advanced, with alpha-blockers and 5-alpha reductase inhibitors remaining primary treatments. New evidence supports the use of phosphodiesterase-5 inhibitors and beta-3 agonists for additional symptom relief. This review focuses on the indications, benefits, and side effects of these pharmacotherapies, while surgical treatments are discussed elsewhere.

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