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GlossaryPDE5 inhibitors

block enzyme to improve blood flow in certain conditions

PDE5 inhibitors, or phosphodiesterase type 5 inhibitors, are a class of medications that block the enzyme PDE5, which is involved in regulating blood flow in the body. By inhibiting this enzyme, these drugs help to relax blood vessels and improve blood flow, making them effective treatments for conditions like erectile dysfunction and pulmonary arterial hypertension.

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research Most Recent Findings of Curative Drugs for Lower Urinary Tract Symptoms in Clinical Practice

January 2019 in “Nihon Yakuri Gakkai nenkai yoshishu”

Current treatments for lower urinary tract symptoms include α1-blockers, 5ARIs, PDE5 inhibitors, anticholinergic agents, and β3-adrenergic receptor agonists.

research The Long Term Effects of Doxazosin, Finasteride, and the Combination on Sexual Function in Men Participating in the MTOPS Study

8 citations, April 2004 in “The Journal of Urology”

Doxazosin and finasteride negatively affect sexual function in men with BPH.

research Impact of Hormones on Female Sexual Function and Dysfunction

3 citations, January 2011 in “Female pelvic medicine & reconstructive surgery”

Hormones significantly affect women's sexual function, and more research is needed to improve treatments for sexual dysfunction with minimal side effects.

Novel Penile Ultrasound Technique to Explain Mechanism of Erectile Dysfunction in Young Patients Using Finasteride for Androgenic Alopecia

research Novel Penile Ultrasound Technique to Explain Mechanism of Erectile Dysfunction in Young Patients Using Finasteride for Androgenic Alopecia

1 citations, February 2018 in “The Journal of Sexual Medicine”

Ultrasound shows 96% of young men with erectile dysfunction after using finasteride have abnormal penile tissue.

research The Urologic Impact of Long-Term Finasteride-1 Mg Use for Androgenic Alopecia: A Matched-Cohort Database Analysis

April 2025 in “The Journal of Urology”

Long-term finasteride use may lower prostate cancer risk but increase the need for erectile dysfunction medication.

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community Finasteride update/information on Penis/Penile Tissue

in Finasteride/Dutasteride 8 upvotes 2 years ago

Finasteride can reduce DHT in the genitalia, potentially causing side effects like reduced erections and penile fibrosis. Using PDE5 inhibitors like Tadalafil or Sildenafil may help maintain penile health and prevent fibrosis.

community Hair Loss Treatment Iceberg Chart

in Satire 1382 upvotes 3 years ago

Hair loss treatments discussed include Minoxidil, Finasteride, RU58841, ass hair transplant, topical Viagra, castration, and transitioning to female. A user mentions an experimental drug called M4U-5 (Mousteride) that turns you into a mouse.

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 135 upvotes 8 months ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

community Why is human evolution like this 😂

in Chat 3 years ago

Why androgenic alopecia affects the scalp rather than other body parts, potential explanations for this phenomenon, treatments available to combat hair loss, and the implications of male attractiveness in modern society.

community Complete Guide to Orally Taking Topical Minoxidil

in DANGEROUS / UNPROVEN 149 upvotes 3 years ago

Taking topical minoxidil orally for hair loss treatment, discussing safety, dosing, side effects, and FAQs. Users express concerns about safety and potential heart damage, while others share experiences and results.

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