The 5α-Reductase Inhibitor Finasteride Increases Suicide-Related Aggressive Behaviors and Blocks Clozapine-Induced Beneficial Effects in an Animal Model of Schizophrenia

    April 2018 in “ Physiology & Behavior ”
    Caroline Maurice-Gelinas, Jessica Deslauriers, Cécile Monpays … Sylvain Grignon
    Studysummary In this study, clozapine reduced suicide-related behaviors in a schizophrenia-like mouse model, but its effects on exploratory behavior were counteracted by the neurosteroid inhibitor finasteride.
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    Research cited in this study 6

    1. The Neurosteroidogenic Enzyme 5α-Reductase Modulates the Role of D1 Dopamine Receptors in Rat Sensorimotor Gating Psychoneuroendocrinology · 2015
    2. Targeting Neurosteroid Synthesis as a Therapy for Schizophrenia-Related Alterations Induced by Early Psychosocial Stress Schizophrenia Research · 2015
    3. Finasteride Administration Potentiates the Disruption of Prepulse Inhibition Induced by Forced Swim Stress Behavioural Brain Research · 2015
    4. Inhibition Of 5α-Reductase Attenuates Behavioral Effects Of D1-, But Not D2-Like Receptor Agonists In C57BL/6 Mice Psychoneuroendocrinology · 2012
    5. Sex Differences in the Effect of Finasteride on Acute Ethanol Withdrawal Severity in C57BL/6J and DBA/2J Mice Neuroscience · 2007
    6. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006

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    1. The 5α-Reductase Inhibitor Finasteride Increases Suicide-Related Aggressive Behaviors and Blocks Clozapine-Induced Beneficial Effects in an Animal Model of Schizophrenia Physiology & Behavior · 2018