The 5α-Reductase Inhibitor Finasteride Increases Suicide-Related Aggressive Behaviors and Blocks Clozapine-Induced Beneficial Effects in an Animal Model of Schizophrenia

April 2018 in “ Physiology & Behavior ”

Caroline Maurice-Gelinas, Jessica Deslauriers, Cécile Monpays, Philippe Sarret, Sylvain Grignon

finasteride 5α-reductase inhibitor neurosteroids Propecia

Studysummary In this study, clozapine reduced suicide-related behaviors in a schizophrenia-like mouse model, but its effects on exploratory behavior were counteracted by the neurosteroid inhibitor finasteride.

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research The Neurosteroidogenic Enzyme 5α-Reductase Modulates the Role of D1 Dopamine Receptors in Rat Sensorimotor Gating

49 citations , September 2015 in “Psychoneuroendocrinology”

This study suggests that the 5α-reductase inhibitor finasteride modulates sensorimotor gating in rats by affecting D1 and D3 receptors, but not D2 receptors, with varying effects based on genetic strain.

research Targeting Neurosteroid Synthesis as a Therapy for Schizophrenia-Related Alterations Induced by Early Psychosocial Stress

24 citations , May 2015 in “Schizophrenia Research”

This study found that inhibiting the enzyme 5α-reductase with finasteride counteracted stress-induced prepulse inhibition deficits in socially isolated rats by altering neuroactive steroid concentrations in the brain.

research Finasteride Administration Potentiates the Disruption of Prepulse Inhibition Induced by Forced Swim Stress

6 citations , April 2015 in “Behavioural Brain Research”

In this study, finasteride was found to potentiate stress-induced disruption in sensory gating of rats by neutralizing the increase in allopregnanolone levels after acute stress.

research Inhibition Of 5α-Reductase Attenuates Behavioral Effects Of D1-, But Not D2-Like Receptor Agonists In C57BL/6 Mice

42 citations , August 2012 in “Psychoneuroendocrinology”

Finasteride reduces certain behaviors caused by D1-like receptor agonists but not by D2-like receptor agonists in mice.

research Sex Differences in the Effect of Finasteride on Acute Ethanol Withdrawal Severity in C57BL/6J and DBA/2J Mice

34 citations , April 2007 in “Neuroscience”

In this study, finasteride altered acute ethanol withdrawal severity differently in male and female mice, highlighting sex differences in sensitivity to changes in neurosteroid levels.

research A New Look at the 5-Alpha-Reductase Inhibitor Finasteride

137 citations , March 2006 in “Cns Drug Reviews”

This review explores finasteride's effects on neuroactive steroid levels and their potential influence on disorders like depression and alcohol withdrawal but reports no new clinical findings.