The 5α-Reductase Inhibitor Finasteride Increases Suicide-Related Aggressive Behaviors and Blocks Clozapine-Induced Beneficial Effects in an Animal Model of Schizophrenia

    April 2018 in “ Physiology & Behavior ”
    Caroline Maurice-Gelinas, Jessica Deslauriers, Cécile Monpays, Philippe Sarret, Sylvain Grignon
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    TLDR Finasteride raises suicide-linked aggression and stops clozapine's positive effects in schizophrenia animals.
    The study found that finasteride, a drug used to treat hair loss, increased suicide-related aggressive behaviors and blocked the beneficial effects of clozapine, a medication used to treat schizophrenia, in an animal model of schizophrenia. The study suggests that neurosteroids may be involved in clozapine effects and suicide-related behaviors. The results suggest that finasteride may have negative effects on mental health and caution should be taken when prescribing it to patients with psychiatric disorders.
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