The Neurosteroidogenic Enzyme 5α-Reductase Modulates the Role of D1 Dopamine Receptors in Rat Sensorimotor Gating

    September 2015 in “ Psychoneuroendocrinology ”
    Roberto Frau, Laura J. Mosher, Valentina Bini … Marco Bortolato
    Studysummary This study suggests that the 5α-reductase inhibitor finasteride modulates sensorimotor gating in rats by affecting D1 and D3 receptors, but not D2 receptors, with varying effects based on genetic strain.
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    Research cited in this study 9

    1. Targeting Neurosteroid Synthesis as a Therapy for Schizophrenia-Related Alterations Induced by Early Psychosocial Stress Schizophrenia Research · 2015
    2. The Implication of Neuroactive Steroids in Tourette's Syndrome Pathogenesis: A Role for 5α-Reductase? Journal of neuroendocrinology · 2013
    3. Inhibition Of 5α-Reductase Attenuates Behavioral Effects Of D1-, But Not D2-Like Receptor Agonists In C57BL/6 Mice Psychoneuroendocrinology · 2012
    4. Inhibition of 5α-Reductase in the Nucleus Accumbens Counters Sensorimotor Gating Deficits Induced by Dopaminergic Activation Psychoneuroendocrinology · 2011
    5. A Preliminary Study of Finasteride in Tourette Syndrome Movement Disorders · 2011
    6. Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders Current Pharmaceutical Design · 2011
    7. Improvement of General Symptoms in a Chronic Psychotic Patient Treated with Finasteride: Case Report Pharmacopsychiatry · 2008
    8. Antipsychotic-Like Properties of 5-Alpha-Reductase Inhibitors Neuropsychopharmacology · 2008
    9. Treatment of Tourette’s Syndrome With Finasteride American Journal of Psychiatry · 2007